In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound

The work aimed at developing a MRI-guided protocol for the visualization of the release of material entrapped in liposomes stimulated by the local application of pulsed low-intensity non-focused ultrasound (pLINFU). The task was achieved by formulating liposomes filled up with the clinically approve...

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Autores: Rizzitelli, Silvia, Giustetto, Pierangela, Boffa, Cinzia, Delli Castelli, Daniela, Cutrin, Juan Carlos, Aime, Silvio, Terreno, Enzo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/7867
Acceso en línea:http://hdl.handle.net/11336/7867
Access Level:acceso abierto
Palabra clave:Drug Release
Theranosis
Liposomes
Ultrasound
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
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spelling In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasoundRizzitelli, SilviaGiustetto, PierangelaBoffa, CinziaDelli Castelli, DanielaCutrin, Juan CarlosAime, SilvioTerreno, EnzoDrug ReleaseTheranosisLiposomesUltrasoundhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The work aimed at developing a MRI-guided protocol for the visualization of the release of material entrapped in liposomes stimulated by the local application of pulsed low-intensity non-focused ultrasound (pLINFU). The task was achieved by formulating liposomes filled up with the clinically approved paramagnetic agent gadoteridol, because the release of the agent from the nanovesicles is accompanied by a significant MRI signal enhancement. The protocol was validated in vivo on mice-bearing subcutaneous syngeneic B16 melanoma and i.v. injected with the paramagnetic liposomes. Upon exposing tumor to pLINFU (3 MHz, insonation time 2 min, duty cycle 50%) few minutes after liposomes injection, a signal enhancement of ca. 35% was detected. The effective release of the agent was confirmed by the strong enhancement measured in kidneys calyx and bladder due to the rapid renal excretion of the agent released in the tumor.From the Clinical EditorIn this paper, a pulsed low-intensity non-focused ultrasound-based technique was used to release a paramagnetic MRI contrast agent from liposomes, demonstrating the feasibility of this triggered release system in a mouse melanoma model for future research applications.Fil: Rizzitelli, Silvia. Universitã â  Di Torino; ItaliaFil: Giustetto, Pierangela. Universitã â  Di Torino; ItaliaFil: Boffa, Cinzia. Universitã â  Di Torino; ItaliaFil: Delli Castelli, Daniela. Universitã â  Di Torino; ItaliaFil: Cutrin, Juan Carlos. Universitã â  Di Torino; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Aime, Silvio. Universitã â  Di Torino; ItaliaFil: Terreno, Enzo. Universitã â  Di Torino; ItaliaElsevier Science2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7867Rizzitelli, Silvia; Giustetto, Pierangela; Boffa, Cinzia; Delli Castelli, Daniela; Cutrin, Juan Carlos; et al.; In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound; Elsevier Science; Nanomedicine-nanotechnology Biology And Medicine; 10; 5; 3-2014; 901-9041549-9634enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1549963414001300info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nano.2014.03.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:10:09Zoai:ri.conicet.gov.ar:11336/7867instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:10:09.362CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
title In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
spellingShingle In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
Rizzitelli, Silvia
Drug Release
Theranosis
Liposomes
Ultrasound
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
title_short In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
title_full In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
title_fullStr In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
title_full_unstemmed In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
title_sort In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound
dc.creator.none.fl_str_mv Rizzitelli, Silvia
Giustetto, Pierangela
Boffa, Cinzia
Delli Castelli, Daniela
Cutrin, Juan Carlos
Aime, Silvio
Terreno, Enzo
author Rizzitelli, Silvia
author_facet Rizzitelli, Silvia
Giustetto, Pierangela
Boffa, Cinzia
Delli Castelli, Daniela
Cutrin, Juan Carlos
Aime, Silvio
Terreno, Enzo
author_role author
author2 Giustetto, Pierangela
Boffa, Cinzia
Delli Castelli, Daniela
Cutrin, Juan Carlos
Aime, Silvio
Terreno, Enzo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Drug Release
Theranosis
Liposomes
Ultrasound
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
topic Drug Release
Theranosis
Liposomes
Ultrasound
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
description The work aimed at developing a MRI-guided protocol for the visualization of the release of material entrapped in liposomes stimulated by the local application of pulsed low-intensity non-focused ultrasound (pLINFU). The task was achieved by formulating liposomes filled up with the clinically approved paramagnetic agent gadoteridol, because the release of the agent from the nanovesicles is accompanied by a significant MRI signal enhancement. The protocol was validated in vivo on mice-bearing subcutaneous syngeneic B16 melanoma and i.v. injected with the paramagnetic liposomes. Upon exposing tumor to pLINFU (3 MHz, insonation time 2 min, duty cycle 50%) few minutes after liposomes injection, a signal enhancement of ca. 35% was detected. The effective release of the agent was confirmed by the strong enhancement measured in kidneys calyx and bladder due to the rapid renal excretion of the agent released in the tumor.From the Clinical EditorIn this paper, a pulsed low-intensity non-focused ultrasound-based technique was used to release a paramagnetic MRI contrast agent from liposomes, demonstrating the feasibility of this triggered release system in a mouse melanoma model for future research applications.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7867
Rizzitelli, Silvia; Giustetto, Pierangela; Boffa, Cinzia; Delli Castelli, Daniela; Cutrin, Juan Carlos; et al.; In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound; Elsevier Science; Nanomedicine-nanotechnology Biology And Medicine; 10; 5; 3-2014; 901-904
1549-9634
url http://hdl.handle.net/11336/7867
identifier_str_mv Rizzitelli, Silvia; Giustetto, Pierangela; Boffa, Cinzia; Delli Castelli, Daniela; Cutrin, Juan Carlos; et al.; In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound; Elsevier Science; Nanomedicine-nanotechnology Biology And Medicine; 10; 5; 3-2014; 901-904
1549-9634
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1549963414001300
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nano.2014.03.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,812455

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