Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment

In high-income countries, more than 90% of children with mature B-cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients...

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Detalles Bibliográficos
Autores: Chantada, Guillermo Luis, Lam, Catherine G., Howard, Scott C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/122807
Acceso en línea:http://hdl.handle.net/11336/122807
Access Level:acceso abierto
Palabra clave:ABANDONMENT
B-CELL LYMPHOMA
BURKITT LYMPHOMA
LOW-INCOME COUNTRIES
MIDDLE-INCOME COUNTRIES
NON-HODGKIN LYMPHOMA
TOXIC DEATH
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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network_acronym_str AR
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repository_id_str
spelling Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonmentChantada, Guillermo LuisLam, Catherine G.Howard, Scott C.ABANDONMENTB-CELL LYMPHOMABURKITT LYMPHOMALOW-INCOME COUNTRIESMIDDLE-INCOME COUNTRIESNON-HODGKIN LYMPHOMATOXIC DEATHhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3In high-income countries, more than 90% of children with mature B-cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients who live far from the cancer centre or face financial barriers to receiving care. In low- and middle-income countries (LMIC), cure rates range from 20% to 70% because of lack of diagnosis, misdiagnosis, abandonment of treatment, toxic death and excess relapse with reduced-intensity regimens. Fortunately, a wide range of successful interventions in LMIC have reduced these causes of avoidable treatment failure. Public awareness campaigns have led to societal awareness of childhood cancer; telepathology has improved diagnosis, even in remote areas; subsidized chemotherapy, transportation, housing and food have reduced abandonment; and hand hygiene, nurse training programmes and health system improvements have reduced toxic death. These interventions can be deployed everywhere and at low cost, so are highly scalable. Children and adolescents with Burkitt lymphoma can be cured in all countries by making a timely correct diagnosis, applying protocols adapted to the local context, preventing abandonment of therapy and avoiding toxic death. Reducing these causes of treatment failure is feasible and highly cost-effective everywhere.Fil: Chantada, Guillermo Luis. Hospital Universitario Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lam, Catherine G.. St. Jude Children's Research Hospital; Estados UnidosFil: Howard, Scott C.. University of Tennessee; Estados UnidosWiley Blackwell Publishing, Inc2019-02-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/122807Chantada, Guillermo Luis; Lam, Catherine G.; Howard, Scott C.; Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 185; 6; 10-2-2019; 1125-11350007-1048CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.15785info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15785info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1111/bjh.15785info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:18:35Zoai:ri.conicet.gov.ar:11336/122807instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:18:35.852CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
title Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
spellingShingle Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
Chantada, Guillermo Luis
ABANDONMENT
B-CELL LYMPHOMA
BURKITT LYMPHOMA
LOW-INCOME COUNTRIES
MIDDLE-INCOME COUNTRIES
NON-HODGKIN LYMPHOMA
TOXIC DEATH
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
title_full Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
title_fullStr Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
title_full_unstemmed Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
title_sort Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment
dc.creator.none.fl_str_mv Chantada, Guillermo Luis
Lam, Catherine G.
Howard, Scott C.
author Chantada, Guillermo Luis
author_facet Chantada, Guillermo Luis
Lam, Catherine G.
Howard, Scott C.
author_role author
author2 Lam, Catherine G.
Howard, Scott C.
author2_role author
author
dc.subject.none.fl_str_mv ABANDONMENT
B-CELL LYMPHOMA
BURKITT LYMPHOMA
LOW-INCOME COUNTRIES
MIDDLE-INCOME COUNTRIES
NON-HODGKIN LYMPHOMA
TOXIC DEATH
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic ABANDONMENT
B-CELL LYMPHOMA
BURKITT LYMPHOMA
LOW-INCOME COUNTRIES
MIDDLE-INCOME COUNTRIES
NON-HODGKIN LYMPHOMA
TOXIC DEATH
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description In high-income countries, more than 90% of children with mature B-cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients who live far from the cancer centre or face financial barriers to receiving care. In low- and middle-income countries (LMIC), cure rates range from 20% to 70% because of lack of diagnosis, misdiagnosis, abandonment of treatment, toxic death and excess relapse with reduced-intensity regimens. Fortunately, a wide range of successful interventions in LMIC have reduced these causes of avoidable treatment failure. Public awareness campaigns have led to societal awareness of childhood cancer; telepathology has improved diagnosis, even in remote areas; subsidized chemotherapy, transportation, housing and food have reduced abandonment; and hand hygiene, nurse training programmes and health system improvements have reduced toxic death. These interventions can be deployed everywhere and at low cost, so are highly scalable. Children and adolescents with Burkitt lymphoma can be cured in all countries by making a timely correct diagnosis, applying protocols adapted to the local context, preventing abandonment of therapy and avoiding toxic death. Reducing these causes of treatment failure is feasible and highly cost-effective everywhere.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/122807
Chantada, Guillermo Luis; Lam, Catherine G.; Howard, Scott C.; Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 185; 6; 10-2-2019; 1125-1135
0007-1048
CONICET Digital
CONICET
url http://hdl.handle.net/11336/122807
identifier_str_mv Chantada, Guillermo Luis; Lam, Catherine G.; Howard, Scott C.; Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 185; 6; 10-2-2019; 1125-1135
0007-1048
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.15785
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15785
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1111/bjh.15785
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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