Lipophilicity of Novel 5-Carbonates of Lamivudine With Antirretroviral Activity. Correlation Between Different Methods
This study reports on the lipophilicity of novel 5′‐carbonates of lamivudine with anti‐HIV activity. Reversed‐phase thin layer chromatography (RP‐TLC), reversed‐phase high performance liquid chromatography (RP‐HPLC), conventional shake flask (log Poct), and the theoretical CLOGP methods were used, i...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/29435 |
| Acceso en línea: | http://hdl.handle.net/11336/29435 |
| Access Level: | acceso abierto |
| Palabra clave: | Lipophilicity Carbonates of Lamivudine Rp-Tlc Rp-Hplc https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | This study reports on the lipophilicity of novel 5′‐carbonates of lamivudine with anti‐HIV activity. Reversed‐phase thin layer chromatography (RP‐TLC), reversed‐phase high performance liquid chromatography (RP‐HPLC), conventional shake flask (log Poct), and the theoretical CLOGP methods were used, in order to establish if the linear relationships between the conventional and chromatographic methods permit an extrapolation procedure. The nature of the organic modifiers used in the chromatographic techniques did not substantially affect the measurement of lipophilicity, since a good correlation between experimental log Poct and extrapolated RP‐TLC and RP‐HPLC values (RMw and log k′w, respectively) supported the validity of the extrapolation technique. |
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