Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding

This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44...

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Detalhes bibliográficos
Autores: Polti, Lucas Fabian, Sicco, Estefanía, Silveira, Felipe Martins, Schuch, Lauren Frenzel, Pereira-Prado, Vanesa, Bologna-Molina, Ronell, Paparella, María Luisa
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:Uruguay
Recursos:Universidad de la República
Repositório:COLIBRI
Idioma:inglês
OAI Identifier:oai:colibri.udelar.edu.uy:20.500.12008/51676
Acesso em linha:https://hdl.handle.net/20.500.12008/51676
Access Level:Acceso aberto
Palavra-chave:Ghost cell
Odontogenic lesions
Calcifying odontogenic cyst
Dentinogenic ghost cell tumor
Granular cells
Immunohistochemistry
QUISTE ODONTOGÉNICO CALCIFICADO
INMUNOHISTOQUÍMICA
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network_acronym_str UY
network_name_str Uruguay
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dc.title.none.fl_str_mv Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
title Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
spellingShingle Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
Polti, Lucas Fabian
Ghost cell
Odontogenic lesions
Calcifying odontogenic cyst
Dentinogenic ghost cell tumor
Granular cells
Immunohistochemistry
QUISTE ODONTOGÉNICO CALCIFICADO
INMUNOHISTOQUÍMICA
title_short Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
title_full Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
title_fullStr Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
title_full_unstemmed Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
title_sort Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
dc.creator.none.fl_str_mv Polti, Lucas Fabian
Sicco, Estefanía
Silveira, Felipe Martins
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Bologna-Molina, Ronell
Paparella, María Luisa
author Polti, Lucas Fabian
author_facet Polti, Lucas Fabian
Sicco, Estefanía
Silveira, Felipe Martins
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Bologna-Molina, Ronell
Paparella, María Luisa
author_role author
author2 Sicco, Estefanía
Silveira, Felipe Martins
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Bologna-Molina, Ronell
Paparella, María Luisa
author2_role author
author
author
author
author
author
dc.contributor.filiacion.none.fl_str_mv Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.
Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.
dc.subject.es.fl_str_mv Ghost cell
Odontogenic lesions
Calcifying odontogenic cyst
Dentinogenic ghost cell tumor
Granular cells
Immunohistochemistry
topic Ghost cell
Odontogenic lesions
Calcifying odontogenic cyst
Dentinogenic ghost cell tumor
Granular cells
Immunohistochemistry
QUISTE ODONTOGÉNICO CALCIFICADO
INMUNOHISTOQUÍMICA
dc.subject.other.es.fl_str_mv QUISTE ODONTOGÉNICO CALCIFICADO
INMUNOHISTOQUÍMICA
description This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-09-17T17:22:19Z
dc.date.available.none.fl_str_mv 2025-09-17T17:22:19Z
dc.date.issued.none.fl_str_mv 2025
dc.type.es.fl_str_mv Artículo
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.citation.es.fl_str_mv Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h.
dc.identifier.issn.none.fl_str_mv 2525-5711
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/51676
dc.identifier.doi.none.fl_str_mv 10.5327/2525-5711.34
identifier_str_mv Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h.
2525-5711
10.5327/2525-5711.34
url https://hdl.handle.net/20.500.12008/51676
dc.language.iso.none.fl_str_mv en_US
eng
language_invalid_str_mv en_US
language eng
dc.relation.none.fl_str_mv Journal of Oral Diagnosis, 2025, 10:e354.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
dc.format.extent.es.fl_str_mv 9 h.
dc.format.mimetype.es.fl_str_mv application/pdf
dc.publisher.es.fl_str_mv Brazilian Society of Oral Medicine and Oral Pathology (SOBEP).
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
instname_str Universidad de la República
instacron_str Universidad de la República
institution Universidad de la República
reponame_str COLIBRI
collection COLIBRI
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spelling Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.2025-09-17T17:22:19Z2025-09-17T17:22:19Z2025Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h.2525-5711https://hdl.handle.net/20.500.12008/5167610.5327/2525-5711.34This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells.Submitted by Farias Verónica (verofariasblundell@gmail.com) on 2025-09-16T20:06:46Z No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10532725255711354.pdf: 13668067 bytes, checksum: 3bae89fbc5f104a278f3c000b6e6d4b1 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2025-09-17T17:22:19Z (GMT). No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10532725255711354.pdf: 13668067 bytes, checksum: 3bae89fbc5f104a278f3c000b6e6d4b1 (MD5) Previous issue date: 20259 h.application/pdfen_USengBrazilian Society of Oral Medicine and Oral Pathology (SOBEP).Journal of Oral Diagnosis, 2025, 10:e354.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Ghost cellOdontogenic lesionsCalcifying odontogenic cystDentinogenic ghost cell tumorGranular cellsImmunohistochemistryQUISTE ODONTOGÉNICO CALCIFICADOINMUNOHISTOQUÍMICAGranular cells in ghost cell odontogenic lesions: an unusual and unexpected findingArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaPolti, Lucas FabianSicco, EstefaníaSilveira, Felipe MartinsSchuch, Lauren FrenzelPereira-Prado, VanesaBologna-Molina, RonellPaparella, María LuisaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/51676/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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públicahttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestkarina.camps@seciu.edu.uyUruguayopendoar:47712025-10-01T17:47:04COLIBRI - Universidad de la Repúblicafalse
score 14.712934

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