Experience with rituximab in refractory idiopathic inflammatory myopathy

Clinical and laboratory characteristics of two patients who received rituximab for refractory idiopathic inflammatory myopathy (IIM) are described. Patients were refractory to conventional treatment with disease-modifying antirheumatic drugs (DMARDs) so they received rituximab 1 g dose every 14 days...

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Detalles Bibliográficos
Autores: García-Salazar, Elmer R., Becerra, Felipe, Chávez, José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Perú
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Idioma:español
OAI Identifier:oai:revistasinvestigacion.unmsm.edu.pe:article/2709
Acceso en línea:https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/2709
Access Level:acceso abierto
Palabra clave:Dermatomiositis
miopatía inflamatoria idiopática refractaria
rituximab.
Dermatomyositis
refractory idiopathic inflammatory myopathy
Descripción
Sumario:Clinical and laboratory characteristics of two patients who received rituximab for refractory idiopathic inflammatory myopathy (IIM) are described. Patients were refractory to conventional treatment with disease-modifying antirheumatic drugs (DMARDs) so they received rituximab 1 g dose every 14 days in two biannual cycle infusions. Data of proximal muscle strength, pathognomonic skin lesions, CPK, SGOT, LDH and ESR, results of electromyography, muscle and skin biopsy were obtained from the medical records. None of the cases presented drug reaction or infections during and following infusions. Rituximab showed effectiveness in clinical and enzymatic response in patients with dermatomyositis refractory to corticosteroids and traditional DMARDs.