Antiinflammatory and antioxidant effects of Jungia rugosa Less (matico de puna) leaves' flavonoids in rats
Objectives: To determine anti-inflammatory and antioxidant activities of Jungia rugosa Less leaves flavones’ fraction. Design: Experimental. Setting: Faculties of Medicine and Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Flavones fraction extracted f...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Perú |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Idioma: | español |
| OAI Identifier: | oai:revistasinvestigacion.unmsm.edu.pe:article/1074 |
| Acceso en línea: | https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1074 |
| Access Level: | acceso abierto |
| Palabra clave: | Jungia rugosa Less flavonoide actividad antiinflamatoria actividad antioxidante flavonoid anti-inflammatory and antioxidant activity |
| Sumario: | Objectives: To determine anti-inflammatory and antioxidant activities of Jungia rugosa Less leaves flavones’ fraction. Design: Experimental. Setting: Faculties of Medicine and Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Flavones fraction extracted from Jungia rugosa Less leaves and rats. Interventions: Jungia rugosa Less leaves collected in Condorcunca’s hill at 3 500 m.a.s.l., Quinua district, Ayacucho department. The anti-inflammatory activity was assessed in vivo in carrageenan-induced paw edema model and 1, 6 interleukins serum levels and C reactive protein (CRP) were measured in blood; granuloma was induced according to Sedwicks and studied by histopathology. The antioxidant effect was investigated in vitro by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical neutralization. Main outcome measures: Anti-inflammatory and antioxidant effects. Results: Inflammation reduced in 43,8% and 1,6 interleukins and CRP levels decreased respectively 80%, 90% and 78% compared to control, in dose-dependent effect (p<0,05), with 97,7% DPPH radicals inhibition. Conclusions: Flavones fraction extracted from Jungia rugosa Less leaves is anti-inflammatory and antioxidant. |
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