Linking chemistry and biology: protein sequences

In the last twenty years, the number of complete genomes that have been sequenced and deposited in data banks has grown dramatically. This abundance in sequence information has supported the creation of the discipline known as  paleogenetics. In this article, without going into complex algorithms, w...

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Detalles Bibliográficos
Autores: Laos, Roberto, Benner, Steven A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Perú
Institución:Pontificia Universidad Católica del Perú
Repositorio:Revistas - Pontificia Universidad Católica del Perú
Idioma:español
inglés
OAI Identifier:oai:ojs.pkp.sfu.ca:article/15502
Acceso en línea:http://revistas.pucp.edu.pe/index.php/quimica/article/view/15502
Access Level:acceso abierto
Palabra clave:Bioinformatics
ancestral proteins
synthetic biology
protein engineering
Bioinformática
proteínas ancestrales
biología sintética
ingeniería de proteínas
Descripción
Sumario:In the last twenty years, the number of complete genomes that have been sequenced and deposited in data banks has grown dramatically. This abundance in sequence information has supported the creation of the discipline known as  paleogenetics. In this article, without going into complex algorithms, we present some key concepts for understanding how proteins have evolved in time. We then illustrate how paleogenetic analysis can be used in biotechnology. These examples highlight the connection between chemistry and biology, two disciplines that twenty years ago seemed to be more different than what they seem to be today.