New oral anticoagulants in thromboembolism prevention in nonvalvular atrial fibrillation

Atrial fibrillation is the most frequent cardiac arrhythmia in clinical practice. The value of anticoagulation with vitamin K antagonists like warfarin in the prevention of embolic phenomena is widely demonstrated but managing is difficult because of its known interactions with other drugs and even...

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Detalles Bibliográficos
Autor: Sosa Rosado, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Perú
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Idioma:español
OAI Identifier:oai:revistasinvestigacion.unmsm.edu.pe:article/2391
Acceso en línea:https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/2391
Access Level:acceso abierto
Palabra clave:Fibrilación auricular
warfarina
inhibidores directos de la trombina
inhibidores directos del factor Xa.
Atrial fibrillation
warfarin
direct thrombin inhibitors
direct factor Xa inhibitors.
Descripción
Sumario:Atrial fibrillation is the most frequent cardiac arrhythmia in clinical practice. The value of anticoagulation with vitamin K antagonists like warfarin in the prevention of embolic phenomena is widely demonstrated but managing is difficult because of its known interactions with other drugs and even food. Looking for the ideal anticoagulant in the last years new antithrombotic agents have appeared and others are in advanced phases of investigation. In the current review results of new anticoagulant agents development and expectations, opportunities and challenges are described in regards to direct thrombin and Xa factor inhibitors.