Performance of the FIB-4 index in esophageal varices screening in patients with the diagnosis of liver cirrhosis
INTRODUCTION: The diagnosis of esophageal varices in cirrhotic patients is made by the upper gastrointestinal endoscopy. Multiple non-invasive predictors have been studied for the diag-nosis of esophageal varices. The objective of this study is to testthe FIB4 index as screening of esophageal varice...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2020 |
| País: | Perú |
| Recursos: | Universidad Peruana de Ciencias Aplicadas |
| Repositório: | UPC-Institucional |
| Idioma: | espanhol |
| OAI Identifier: | oai:repositorioacademico.upc.edu.pe:10757/655701 |
| Acesso em linha: | http://hdl.handle.net/10757/655701 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Endoscopy Digestive system Liver cirrhosis Esophageal and gastric varices Diag-nostic techniques Endoscopía del sistema digestivo Cirrosis hepática Várices esofágicas y gastricas Técnicas de diagnóstico del sistema digestivo https://purl.org/pe-repo/ocde/ford#3.00.00 |
| Resumo: | INTRODUCTION: The diagnosis of esophageal varices in cirrhotic patients is made by the upper gastrointestinal endoscopy. Multiple non-invasive predictors have been studied for the diag-nosis of esophageal varices. The objective of this study is to testthe FIB4 index as screening of esophageal varices in patients with liver cirrhosis. MATERIALS AND METHODS: A cross-sectional analytic study was developed in four national hospital using hepatic cirrhosis patient's medi-cal files. We assessed the information using univariate and bivariate analysis, sensitivity, speci-ficity, predictive positive and negative value, the positive and negative likelihood ratio calcu-lation of the esophageal varices screening and its size. We built ROC curve for every analysis group. RESULTS: The study included 289 liver cirrhosis patients. Most of the patients were male (54.33%). 77.85% patients had esophageal varices. The distribution of varices was 19.03%, 35.99% and 22.84% for large, medium and small varices, respectively. In the FIB-4 index analysis for the presence of varices, it was found a sensitivity of 81.3%, specificity of 37.5% (AUC: 0.57). The calculation for variceal size showed a sensitivity of 81.8%, specificity of 23.9% (AUC: 0.50). In the analysis of FIB-4 index for prophylaxis groups was found a sensitivity of 81.8% and a specificity of 28.5% (AUC: 0.54). CONCLUSIONS: The FIB-4 index has no good performance in the screening for the presence of esophageal varices and its size in liver cirrhosis patients. |
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