Hypoglycemic effect of aqueous and ethanol extracts of Psidium guajava L. (guajava) in alloxan-induced diabetic rats
Objective: To evaluate antidiabetic activity of water and ethanol extracts from Psidium guajava L. leaves in alloxan-induced diabetic rats. Material and Methods: Hyperglycemia was induced in albino rats by administering alloxan monohydrate (100 mg/kg i.p.). Water extract at a dose of 250 mg/kg was a...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Perú |
| Institución: | Universidad de San Martín de Porres |
| Repositorio: | Horizonte médico |
| Idioma: | español |
| OAI Identifier: | oai:horizontemedico.usmp.edu.pe:article/279 |
| Acceso en línea: | https://horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/279 |
| Access Level: | acceso abierto |
| Palabra clave: | Psidium guajava L. Diabetes mellitus Antidiabetic Alloxan Blood glucose Antidiabéticos Aloxano Glucosa sanguínea |
| Sumario: | Objective: To evaluate antidiabetic activity of water and ethanol extracts from Psidium guajava L. leaves in alloxan-induced diabetic rats. Material and Methods: Hyperglycemia was induced in albino rats by administering alloxan monohydrate (100 mg/kg i.p.). Water extract at a dose of 250 mg/kg was administered at a single dose, while ethanol extracts at doses of 250 and 500 mg/kg were also administered at a single dose. Blood glucose was determined two hours after administering the extracts. Results: The addition of water and ethanol extracts of Psidium guajava L. tended to decrease the blood glucose concentration. The water extract at a concentration of 250 mg/kg was found to be more potent than ethanol extracts with the lowest mean glucose concentration of 86.67 mg/dL two hours after it was administered. The effect of ethanol extract was only observed at the concentration of 500 mg/kg with a slight decrease in blood glucose. Conclusion: This study indicated a significant antidiabetic activity of water extract of Psidium guajava L. in alloxan induced diabetic rats. |
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