Soya effects on post menopausal endometrial mucosa
Objective: To determine endometrial morphology and estrogen receptors expression changes in post menopausal women following oral soya treatment. Design: Descriptve, observational, longitudinal and prospective study. Setting: Pathology Institute, San Marcos National Major University. Patients: Twenty...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Perú |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Idioma: | español |
| OAI Identifier: | oai:revistasinvestigacion.unmsm.edu.pe:article/1247 |
| Acceso en línea: | https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1247 |
| Access Level: | acceso abierto |
| Palabra clave: | Soya posmenopausia menopausia endometrio Soybeans postmenopause menopause endometrium |
| Sumario: | Objective: To determine endometrial morphology and estrogen receptors expression changes in post menopausal women following oral soya treatment. Design: Descriptve, observational, longitudinal and prospective study. Setting: Pathology Institute, San Marcos National Major University. Patients: Twenty-two post menopausal women treated with soya. Interventions: Histological and immunohistochemical studies were done in endometrium aspiration biopsies before and after 6 months treatment with 60 g oral soya per day. Main outcome measures: Endometrium histology and estrogen and progesterone receptors expression changes. Results: Age ranged between 46 and 65 years, 53 years average. There was apparent vasomotor symptoms improvement. Endometrium before soya treatment was atrophic in 19 patients (86%) and inactive in 3 (14%). Following soya treatment 17 (77,3%) persisted atrophic, 4 (18,2%) were inactive and one became proliferative. Estrogen receptor expression was negative before soya treatment in 19 patients (86%) and 16 (76%) remained negative following treatment. Conclusions: Post menopausal women treated with soya during 6 months showed persistence of atrophic endometrium and negative expression for estrogen receptors |
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