Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation

TP53 interacts with the genes CDKN1A, CSNK1A1, CSNK1D, BAX, ATM, MDM2, HIF1A,SP1. This consensus network has many binding regions involved in phosphorylation. To find whether or not the interactions are involved in ionizing radiation (IR), we used protein interaction mining and visualization tools t...

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Detalles Bibliográficos
Autores: Pineda, Roberto, Suravajhala, Prashanth, Vásquez, Silvia, Chandrasekharan, Mohanalatha
Tipo de recurso: artículo
Fecha de publicación:2014
País:Perú
Institución:Instituto Peruano de Energía Nuclear
Repositorio:IPEN-Institucional
Idioma:inglés
OAI Identifier:oai:repositorio.ipen.gob.pe:20.500.13054/129
Acceso en línea:https://hdl.handle.net/20.500.13054/129
Access Level:acceso abierto
Palabra clave:Radiaciones ionizantes
Efectos biológicos de las radiaciones
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spelling Pineda, RobertoSuravajhala, PrashanthVásquez, SilviaChandrasekharan, MohanalathaVásquez, SilviaPineda, RobertoChandrasekharan, MohanalathaSuravajhala, Prashanth2014-04-24T20:06:05Z2014-04-24T20:06:05Z2014-01Vásquez S, Pineda R, Chandrasekharan M, Suravajhala P. Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation. Informe Científico Tecnológico. 2012; Volumen 12, p. 49-50.1684-1662https://hdl.handle.net/20.500.13054/129TP53 interacts with the genes CDKN1A, CSNK1A1, CSNK1D, BAX, ATM, MDM2, HIF1A,SP1. This consensus network has many binding regions involved in phosphorylation. To find whether or not the interactions are involved in ionizing radiation (IR), we used protein interaction mining and visualization tools to decipher the network. We conclude that ATM, PCNA, TP53 and CDKN1A show protein interactions on cellular response to IR.TP53 interactúa con los genes CDKN1A, CSNK1A1, CSNK1D, BAX, ATM, MDM2, HIF1A y SP1. La red consensual mencionada presenta varias regiones de unión que intervienen durante la fosforilación. Para encontrar si estas interacciones participan o no en la respuesta a la radiación ionizante (IR) analizamos la minería de interacciones proteicas y las herramientas de visualización para descifrar la red. Concluimos que ATM, PCNA, TP53 y CDKN1A presentan interacciones proteicas en la respuesta celular a IR.Instituto Peruano de Energía Nuclearapplication/pdfengLimaPEinfo:eu-repo/semantics/openAccessInstituto Peruano de Energía NuclearRepositorio Institucional del Instituto Peruano de Energía Nuclearreponame:IPEN-Institucionalinstname:Instituto Peruano de Energía Nuclearinstacron:IPENRadiaciones ionizantesEfectos biológicos de las radiacionesProtein interactors of the cellular tumor antigen p53 with response to ionizing radiationinfo:eu-repo/semantics/articleORIGINALp 49-50 - ICT-2012.pdfp 49-50 - ICT-2012.pdfapplication/pdf162424https://repositorio.ipen.gob.pe/bitstream/20.500.13054/129/3/p%2049-50%20-%20ICT-2012.pdf3e801b61b5b19052c8a5fbe99c491d6cMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-8103https://repositorio.ipen.gob.pe/bitstream/20.500.13054/129/2/license.txt7ecf7b0639239de61a3a1ede9c397fecMD52TEXTp 49-50 - ICT-2012.pdf.txtp 49-50 - ICT-2012.pdf.txtExtracted texttext/plain6895https://repositorio.ipen.gob.pe/bitstream/20.500.13054/129/4/p%2049-50%20-%20ICT-2012.pdf.txt60c55138e3417ae87080ea4dd62e07f0MD54THUMBNAILp 49-50 - ICT-2012.pdf.jpgp 49-50 - ICT-2012.pdf.jpgGenerated Thumbnailimage/jpeg18936https://repositorio.ipen.gob.pe/bitstream/20.500.13054/129/5/p%2049-50%20-%20ICT-2012.pdf.jpgc7f395cf6c6f45fca6e6f4aa4716c8e9MD5520.500.13054/129oai:repositorio.ipen.gob.pe:20.500.13054/1292022-02-07 18:04:52.523Repositorio Institucional del Instituto Peruano de Energía Nuclearrepositorio@ipen.gob.peU2UgRGlzdHJpYnV5ZSBiYWpvIHVuYSBMaWNlbmNpYSBDcmVhdGl2ZSBDb21tb25zIEF0cmlidWNpw7NuLU5vQ29tZXJjaWFsLVNpbkRlcml2YXIgNC4wIEludGVybmFjaW9uYWwuCg==
dc.title.es_PE.fl_str_mv Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
title Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
spellingShingle Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
Pineda, Roberto
Radiaciones ionizantes
Efectos biológicos de las radiaciones
title_short Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
title_full Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
title_fullStr Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
title_full_unstemmed Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
title_sort Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
dc.creator.none.fl_str_mv Pineda, Roberto
Suravajhala, Prashanth
Vásquez, Silvia
Chandrasekharan, Mohanalatha
Vásquez, Silvia
Pineda, Roberto
Chandrasekharan, Mohanalatha
Suravajhala, Prashanth
author Pineda, Roberto
author_facet Pineda, Roberto
Suravajhala, Prashanth
Vásquez, Silvia
Chandrasekharan, Mohanalatha
author_role author
author2 Suravajhala, Prashanth
Vásquez, Silvia
Chandrasekharan, Mohanalatha
author2_role author
author
author
dc.subject.es_PE.fl_str_mv Radiaciones ionizantes
Efectos biológicos de las radiaciones
topic Radiaciones ionizantes
Efectos biológicos de las radiaciones
description TP53 interacts with the genes CDKN1A, CSNK1A1, CSNK1D, BAX, ATM, MDM2, HIF1A,SP1. This consensus network has many binding regions involved in phosphorylation. To find whether or not the interactions are involved in ionizing radiation (IR), we used protein interaction mining and visualization tools to decipher the network. We conclude that ATM, PCNA, TP53 and CDKN1A show protein interactions on cellular response to IR.
publishDate 2014
dc.date.accessioned.none.fl_str_mv 2014-04-24T20:06:05Z
dc.date.available.none.fl_str_mv 2014-04-24T20:06:05Z
dc.date.issued.fl_str_mv 2014-01
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dc.identifier.citation.es_PE.fl_str_mv Vásquez S, Pineda R, Chandrasekharan M, Suravajhala P. Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation. Informe Científico Tecnológico. 2012; Volumen 12, p. 49-50.
dc.identifier.issn.none.fl_str_mv 1684-1662
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.13054/129
identifier_str_mv Vásquez S, Pineda R, Chandrasekharan M, Suravajhala P. Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation. Informe Científico Tecnológico. 2012; Volumen 12, p. 49-50.
1684-1662
url https://hdl.handle.net/20.500.13054/129
dc.language.iso.es_PE.fl_str_mv eng
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dc.publisher.es_PE.fl_str_mv Lima
dc.publisher.country.es_PE.fl_str_mv PE
dc.source.es_PE.fl_str_mv Instituto Peruano de Energía Nuclear
Repositorio Institucional del Instituto Peruano de Energía Nuclear
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