FOXP3 expression in T-cell lymphoma: a 47-case study in Edgardo Rebagliati-Martins Hospital; EsSalud, Lima, Peru
Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance.Objective: To determine the specificity and prognostic value of Foxp...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | Perú |
| Institución: | Colegio Médico del Perú |
| Repositorio: | Acta Médica Peruana |
| Idioma: | español |
| OAI Identifier: | oai:amp.cmp.org.pe:article/1497 |
| Acceso en línea: | https://amp.cmp.org.pe/index.php/AMP/article/view/1497 |
| Access Level: | acceso abierto |
| Palabra clave: | Foxp3 Linfoma de células T ATLL T-cell lymphoma |
| Sumario: | Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance.Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma.Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004.Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATLL cases.Conclusion: Foxp3 expression can be seen both in ATLL as in LTPNE. |
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