Hepatoprotective effect of hydroalcoholic extract of Desmodium molliculum (“manayupa”) in rats with hepatic intoxication induced by paracetamol
Objective: To determine the hepatoprotective effect of the hydroalcoholic extract of Desmodium molliculum (“manayupa”) at different concentrations (50, 500 and 800 mg/kg), and also to evaluate its active metabolites. Materials and Methods: Hydroalcoholic extract of D. molliculum was applied to Holtz...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | Perú |
| Institución: | Universidad María Auxiliadora |
| Repositorio: | Agora |
| Idioma: | español |
| OAI Identifier: | oai:revistaagora.com:article/103 |
| Acceso en línea: | https://revistaagora.com/index.php/cieUMA/article/view/103 |
| Access Level: | acceso abierto |
| Palabra clave: | hepatotoxicidad paracetamol Desmodium molliculum hepatotoxicity |
| Sumario: | Objective: To determine the hepatoprotective effect of the hydroalcoholic extract of Desmodium molliculum (“manayupa”) at different concentrations (50, 500 and 800 mg/kg), and also to evaluate its active metabolites. Materials and Methods: Hydroalcoholic extract of D. molliculum was applied to Holtzman rats randomized into six groups (n = 5), which received the following treatments, for ten days, via peroral: groups I and II: physiological serum 10 mL/kg; group III: silymarin 100 mg/kg; Group IV: 50 mg/kg; group V: 500 mg/kg and group VI: 800 mg/kg of the hydroalcoholic extract. On the sixth day of treatment, rats from groups II to VI received paracetamol at 400 mg/kg perorally, with one hour difference from previous treatment, until complete ten days. Results: According to the doses administered, it was observed that the extract of 500 mg/kg and 800 mg/kg of the hydroalcoholic extract showed the largest hepatoprotective effect. Conclusions: The hydroalcoholic extract of Desmodium molliculum (“manayupa”) showed an hepatoprotective effect. |
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