TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes

Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 d...

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Autores: Velasco Chong, Jonas Roberto, Oscar Herrera Calderón, Juan Pedro Rojas Armas, Renán Dilton Hañari Quispe, Gilmar Peña Rojas, Vidalina Andía Ayme, Andres F. Yepes Perez, Cristian Aguilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Perú
Institución:Universidad Continental
Repositorio:CONTINENTAL-Institucional
Idioma:inglés
OAI Identifier:oai:repositorio.continental.edu.pe:20.500.12394/8504
Acceso en línea:https://hdl.handle.net/20.500.12394/8504
https://doi.org/10.3390/foods9060719
Access Level:acceso abierto
Palabra clave:Productos agropecuarios
Tocosh
Papas
Fermentación
https://purl.org/pe-repo/ocde/ford#4.01.01
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dc.title.es_ES.fl_str_mv TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
title TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
spellingShingle TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
Velasco Chong, Jonas Roberto
Productos agropecuarios
Tocosh
Papas
Fermentación
https://purl.org/pe-repo/ocde/ford#4.01.01
title_short TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
title_full TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
title_fullStr TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
title_full_unstemmed TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
title_sort TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
dc.creator.none.fl_str_mv Velasco Chong, Jonas Roberto
Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
author Velasco Chong, Jonas Roberto
author_facet Velasco Chong, Jonas Roberto
Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
author_role author
author2 Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
author2_role author
author
author
author
author
author
author
dc.subject.es_ES.fl_str_mv Productos agropecuarios
Tocosh
Papas
Fermentación
topic Productos agropecuarios
Tocosh
Papas
Fermentación
https://purl.org/pe-repo/ocde/ford#4.01.01
dc.subject.ocde.es_ES.fl_str_mv https://purl.org/pe-repo/ocde/ford#4.01.01
description Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2021-02-25T18:12:41Z
dc.date.available.none.fl_str_mv 2021-02-25T18:12:41Z
dc.date.issued.fl_str_mv 2020
dc.type.es_ES.fl_str_mv info:eu-repo/semantics/article
dc.type.version.es_ES.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.citation.es_ES.fl_str_mv Velasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods9060719
dc.identifier.issn.es_ES.fl_str_mv 2304-8158
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12394/8504
dc.identifier.journal.es_ES.fl_str_mv Foods
dc.identifier.doi.es_ES.fl_str_mv https://doi.org/10.3390/foods9060719
identifier_str_mv Velasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods9060719
2304-8158
Foods
url https://hdl.handle.net/20.500.12394/8504
https://doi.org/10.3390/foods9060719
dc.language.iso.es_ES.fl_str_mv eng
language eng
dc.relation.es_ES.fl_str_mv https://www.mdpi.com/2304-8158/9/6/719/htm
dc.rights.es_ES.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.es_ES.fl_str_mv https://creativecommons.org/licenses/by/4.0/
dc.rights.license.es_ES.fl_str_mv Attribution 4.0 International (CC BY 4.0)
dc.rights.accessRights.es_ES.fl_str_mv Acceso abierto
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
Attribution 4.0 International (CC BY 4.0)
Acceso abierto
dc.format.es_ES.fl_str_mv application/pdf
dc.format.extent.es_ES.fl_str_mv 16 páginas
dc.publisher.es_ES.fl_str_mv Universidad Continental
dc.source.es_ES.fl_str_mv Universidad Continental
Repositorio Institucional - Continental
dc.source.none.fl_str_mv reponame:CONTINENTAL-Institucional
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instname_str Universidad Continental
instacron_str CONTINENTAL
institution CONTINENTAL
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collection CONTINENTAL-Institucional
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spelling 2021-02-25T18:12:41Z2021-02-25T18:12:41Z2020Velasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods90607192304-8158https://hdl.handle.net/20.500.12394/8504Foodshttps://doi.org/10.3390/foods9060719Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.application/pdf16 páginasengUniversidad Continentalhttps://www.mdpi.com/2304-8158/9/6/719/htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Attribution 4.0 International (CC BY 4.0)Acceso abiertoUniversidad ContinentalRepositorio Institucional - Continentalreponame:CONTINENTAL-Institucionalinstname:Universidad Continentalinstacron:CONTINENTALProductos agropecuariosTocoshPapasFermentaciónhttps://purl.org/pe-repo/ocde/ford#4.01.01TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionVelasco Chong, Jonas RobertoOscar Herrera CalderónJuan Pedro Rojas ArmasRenán Dilton Hañari QuispeRenán Dilton Hañari QuispeGilmar Peña RojasVidalina Andía AymeVidalina Andía AymeAndres F. Yepes PerezCristian AguilarLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.continental.edu.pe/backend/api/core/bitstreams/88960883-e170-4e75-af26-711ac4082bd2/download8a4605be74aa9ea9d79846c1fba20a33MD5120.500.12394/8504oai:repositorio.continental.edu.pe:20.500.12394/85042021-02-25 13:12:41.437https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessmetadata.onlyhttps://repositorio.continental.edu.peRepositorio de la Universidad Continentalrepositorio@continental.edu.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