Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.

Contrary to the hypothesis of genetic predisposition in the pathogenesis of Parkinson discase as proposed by many researchers, we suggest that an impairment of blood flow to the substantia nigra is the primary pathological process of this disease, not necessarily related to aging. Conclusion: Based...

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Author: Rafael, Hernando
Format: article
Status:Published version
Publication Date:1996
Country:Perú
Institution:Universidad Nacional Mayor de San Marcos
Repository:Revistas - Universidad Nacional Mayor de San Marcos
Language:Spanish
OAI Identifier:oai:revistasinvestigacion.unmsm.edu.pe:article/4894
Online Access:https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4894
Access Level:Open access
Keyword:Substantía nigra
Parkinson disease
Crebral revascularization
Omentum
Sustancia nigra
Enfermedad de Parkinson
Revascularización cerebral
Epiplon use omento
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oai_identifier_str oai:revistasinvestigacion.unmsm.edu.pe:article/4894
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repository_id_str
spelling Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.Patogénesis de la Enfermedad de Parkinson. Un Análisis Microvascular Y NeuroquímicoRafael, HernandoSubstantía nigraParkinson diseaseCrebral revascularizationOmentumSustancia nigraEnfermedad de ParkinsonRevascularización cerebralEpiplon use omentoContrary to the hypothesis of genetic predisposition in the pathogenesis of Parkinson discase as proposed by many researchers, we suggest that an impairment of blood flow to the substantia nigra is the primary pathological process of this disease, not necessarily related to aging. Conclusion: Based ¡n histopathological and neurochenfical findings ¡n dopaminergic neurons, Parkinson's discase is due to a suboptinial and chronic reduction of arteria¡ blood flow to the mesencephalon. Therefore, revascularization of the catecholaminergic nuclei is an aim to be considered.Al contrario de la hipótesis sobre una predisposición genética en la patogénesis de la enfermedad de Parkinson, propuesta por muchos investigadores, nosotros creemos que un deterioro del flujo sanguíneo a la sustancia negra es la clave en el proceso patológico primario de esta enfermedad, sin estar relacionado, necesariamente, con el envejecimiento. Conclusión: Basado en hallazgos histopatológicos y neuroquímicos en las neuronas dopaminérgicas, la enfermedad de Parkinson se debe a una reducción subóptima y crónica del flujo sanguíneo arterial al mesencéfalo. Por tanto, la revascularización a los núcleos catecolaminérgicos es una meta por resolver.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana1996-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/489410.15381/anales.v57i4.4894Anales de la Facultad de Medicina; Vol. 57 No. 4 (1996); 268-273Anales de la Facultad de Medicina; Vol. 57 Núm. 4 (1996); 268-2731609-94191025-5583reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4894/3958Derechos de autor 1996 Hernando Rafaelhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:revistasinvestigacion.unmsm.edu.pe:article/48942020-04-12T18:12:09Z
dc.title.none.fl_str_mv Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
Patogénesis de la Enfermedad de Parkinson. Un Análisis Microvascular Y Neuroquímico
title Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
spellingShingle Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
Rafael, Hernando
Substantía nigra
Parkinson disease
Crebral revascularization
Omentum
Sustancia nigra
Enfermedad de Parkinson
Revascularización cerebral
Epiplon use omento
title_short Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
title_full Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
title_fullStr Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
title_full_unstemmed Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
title_sort Pathogenesis of parkinsoys disease. Microvascular and neurochemical analysis.
dc.creator.none.fl_str_mv Rafael, Hernando
author Rafael, Hernando
author_facet Rafael, Hernando
author_role author
dc.subject.none.fl_str_mv Substantía nigra
Parkinson disease
Crebral revascularization
Omentum
Sustancia nigra
Enfermedad de Parkinson
Revascularización cerebral
Epiplon use omento
topic Substantía nigra
Parkinson disease
Crebral revascularization
Omentum
Sustancia nigra
Enfermedad de Parkinson
Revascularización cerebral
Epiplon use omento
description Contrary to the hypothesis of genetic predisposition in the pathogenesis of Parkinson discase as proposed by many researchers, we suggest that an impairment of blood flow to the substantia nigra is the primary pathological process of this disease, not necessarily related to aging. Conclusion: Based ¡n histopathological and neurochenfical findings ¡n dopaminergic neurons, Parkinson's discase is due to a suboptinial and chronic reduction of arteria¡ blood flow to the mesencephalon. Therefore, revascularization of the catecholaminergic nuclei is an aim to be considered.
publishDate 1996
dc.date.none.fl_str_mv 1996-12-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4894
10.15381/anales.v57i4.4894
url https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4894
identifier_str_mv 10.15381/anales.v57i4.4894
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4894/3958
dc.rights.none.fl_str_mv Derechos de autor 1996 Hernando Rafael
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 1996 Hernando Rafael
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
dc.source.none.fl_str_mv Anales de la Facultad de Medicina; Vol. 57 No. 4 (1996); 268-273
Anales de la Facultad de Medicina; Vol. 57 Núm. 4 (1996); 268-273
1609-9419
1025-5583
reponame:Revistas - Universidad Nacional Mayor de San Marcos
instname:Universidad Nacional Mayor de San Marcos
instacron:UNMSM
instname_str Universidad Nacional Mayor de San Marcos
instacron_str UNMSM
institution UNMSM
reponame_str Revistas - Universidad Nacional Mayor de San Marcos
collection Revistas - Universidad Nacional Mayor de San Marcos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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