Seronegative autoimmune encephalitis associated with COVID-19: case report
Autoimmune encephalitis has been reported to be temporarily associated with different previous viral infections, but to date its association with COVID-19 has been rarely described. The case of a 47-year-old, self-sufficient woman with no history of COVID-19 vaccination, with respiratory symptoms an...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | Perú |
| Institución: | Universidad Peruana Cayetano Heredia |
| Repositorio: | Revistas - Universidad Peruana Cayetano Heredia |
| Idioma: | inglés |
| OAI Identifier: | oai:revistas.upch.edu.pe:article/5254 |
| Acceso en línea: | https://revistas.upch.edu.pe/index.php/RNP/article/view/5254 |
| Access Level: | acceso abierto |
| Palabra clave: | encefalitis autoinmune enfermedad por coronavirus 2019 (COVID-19) manifestación neurológica inmunoterapia anticuerpo autoimmune encephalitis coronavirus disease-2019 (COVID-19) neurological manifestation immune therapy antibody |
| Sumario: | Autoimmune encephalitis has been reported to be temporarily associated with different previous viral infections, but to date its association with COVID-19 has been rarely described. The case of a 47-year-old, self-sufficient woman with no history of COVID-19 vaccination, with respiratory symptoms and a positive antigen test for SARS CoV-2 infection, is reported. She was initially seen at the ER of a local hospital, with a history of heteroaggressiveness, akinetic mutism, epileptic crisis, and hyperreflexia. Negative infectious, autoimmune and neoplastic tests. The autoimmune encephalitis panel in CSF was negative. We administered empirical treatment with methylprednisolone and immunoglobulin, without a favorable therapeutic response; so treatment with cyclophosphamide was initiated with a favorable clinical evolution, but with severe residual neurocognitive manifestations. The fact that the initial clinical presentation was severe and unresponsive to first-line treatment despite being timely employed, could indicate a greater probability of long-term sequelae. |
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