NK cells during dengue disease and their recognition of dengue virus-infected cells

The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replica...

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Detalles Bibliográficos
Autores: Beltran, Davis, López-Vergès, Sandra
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Panamá
Institución:Instituto Conmemorativo Gorgas de Estudios de la Salud
Repositorio:Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud
Idioma:inglés
OAI Identifier:oai:riicges.gorgas.gob.pa:123456789/62
Acceso en línea:http://riicges.gorgas.gob.pa/handle/123456789/62
Access Level:acceso abierto
Palabra clave:dengue
NK cell
NK receptor
NK ligand
innate immune response
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repository_id_str
spelling NK cells during dengue disease and their recognition of dengue virus-infected cellsBeltran, DavisLópez-Vergès, SandradengueNK cellNK receptorNK ligandinnate immune responseThe innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.Frontiers in Immunology2020-01-17T18:35:18Z2020-01-17T18:35:18Z2014-05-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://riicges.gorgas.gob.pa/handle/123456789/62enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/reponame:Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Saludinstname:Instituto Conmemorativo Gorgas de Estudios de la Saludinstacron:ICGES2020-06-23T16:15:57Zmail@mail.com -
dc.title.none.fl_str_mv NK cells during dengue disease and their recognition of dengue virus-infected cells
title NK cells during dengue disease and their recognition of dengue virus-infected cells
spellingShingle NK cells during dengue disease and their recognition of dengue virus-infected cells
Beltran, Davis
dengue
NK cell
NK receptor
NK ligand
innate immune response
title_short NK cells during dengue disease and their recognition of dengue virus-infected cells
title_full NK cells during dengue disease and their recognition of dengue virus-infected cells
title_fullStr NK cells during dengue disease and their recognition of dengue virus-infected cells
title_full_unstemmed NK cells during dengue disease and their recognition of dengue virus-infected cells
title_sort NK cells during dengue disease and their recognition of dengue virus-infected cells
dc.creator.none.fl_str_mv Beltran, Davis
López-Vergès, Sandra
author Beltran, Davis
author_facet Beltran, Davis
López-Vergès, Sandra
author_role author
author2 López-Vergès, Sandra
author2_role author
dc.subject.none.fl_str_mv dengue
NK cell
NK receptor
NK ligand
innate immune response
topic dengue
NK cell
NK receptor
NK ligand
innate immune response
description The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-05
2020-01-17T18:35:18Z
2020-01-17T18:35:18Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://riicges.gorgas.gob.pa/handle/123456789/62
url http://riicges.gorgas.gob.pa/handle/123456789/62
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Immunology
publisher.none.fl_str_mv Frontiers in Immunology
dc.source.none.fl_str_mv reponame:Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud
instname:Instituto Conmemorativo Gorgas de Estudios de la Salud
instacron:ICGES
instname_str Instituto Conmemorativo Gorgas de Estudios de la Salud
instacron_str ICGES
institution ICGES
reponame_str Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud
collection Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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score 15,811543

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