Intermittent fasting: a strategy to counteract aging linked to oxidative stress

Aging is a multifactorial deterioration process that occurs in the life of an organism, which seems to be linked to oxidative stress. Intermittent fasting (IF) consists of food restriction with intermediate periods of regular food intake repeatedly. Various studies in human beings and experimental a...

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Autores: Hidalgo-Silva , Diana, López-Noguerola , José Sócrates, Sánchez-Gutiérrez , Manuel, Madrigal-Santillán , Eduardo Osiris, Izquierdo-Vega, Jeannett Alejandra
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:México
Institución:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
Repositorio:Mexican Journal of Medical Research
Idioma:inglés
OAI Identifier:oai:repository.uaeh.edu.mx:article/8526
Acceso en línea:https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/8526
Access Level:acceso abierto
Palabra clave:Autophagy
intermittent fasting
aging
oxidative stress
caloric restriction
Autofagia
ayuno intermitente
envejecimiento
estrés oxidativo
restricción calórica
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spelling Intermittent fasting: a strategy to counteract aging linked to oxidative stressAyuno intermitente: una estrategia para contrarrestar el envejecimiento vinculado al estrés oxidativo Hidalgo-Silva , Diana López-Noguerola , José Sócrates Sánchez-Gutiérrez , Manuel Madrigal-Santillán , Eduardo OsirisIzquierdo-Vega, Jeannett AlejandraAutophagyintermittent fastingagingoxidative stresscaloric restrictionAutofagiaayuno intermitenteenvejecimientoestrés oxidativorestricción calóricaAging is a multifactorial deterioration process that occurs in the life of an organism, which seems to be linked to oxidative stress. Intermittent fasting (IF) consists of food restriction with intermediate periods of regular food intake repeatedly. Various studies in human beings and experimental animal models have shown that intermittent fasting counteracts various alterations associated with age and weight loss, a decrease in the concentration of insulin, glucose, and serum lipids, and oxidative stress, improving antioxidant defense. This review summarizes the evidence available to date in PubMed to analyze the effects of IF on the aging process and its link with oxidative stress. The results suggested that food restriction on alternate days and with a time restriction improves aging processes by decreasing oxidative stress markers and increasing autophagy related to longevity. IF represents a promising non-pharmacological alternative to improve health in the adult population. However, more studies are required to know the chronic effect of fasting and recognize its effects as a therapy in diseases associated with aging.El envejecimiento es un proceso de deterioro multifactorial que ocurre en la vida de un organismo, el cual parece estar vinculado con el estrés oxidativo. El ayuno intermitente (AI) consiste en la restricción de alimentos con periodos intermedios de ingesta normal de alimentos de forma recurrente. Diversos estudios en seres humanos y modelos animales de experimentación han demostrado que el ayuno intermitente contrarresta varias alteraciones asociadas con la edad además de la pérdida de peso, la disminución en la concentración de insulina, glucosa y lípidos séricos y el estrés oxidativo, mejorando la defensa antioxidante. La presente revisión resume la evidencia disponible a la fecha en PubMed para analizar los efectos del (AI) en el proceso de envejecimiento y su vinculación con el estrés oxidativo. Los resultados sugieren que la restricción de alimentos en días alternos y con restricción de tiempo mejoran los procesos del envejecimiento al disminuir los marcadores del estrés oxidativo, y aumentar la autofagia que se relaciona con la longevidad. El AI representa una alternativa no farmacológica prometedora para mejorar la salud en población adulta. Sin embargo, se requieren de más estudios en población para conocer el efecto crónico del ayuno y reconocer sus efectos como terapia en enfermedades asociadas al envejecimiento.Universidad Autónoma del Estado de Hidalgo2022-07-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/852610.29057/mjmr.v10i20.8526Mexican Journal of Medical Research ICSA; Vol 10 No 20 (2022): Mexican Journal of Medical Research ICSA; 16-24Mexican Journal of Medical Research ICSA; Vol. 10 Núm. 20 (2022): Mexican Journal of Medical Research ICSA; 16-242007-523510.29057/mjmr.v10i20reponame:Mexican Journal of Medical Researchinstname:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGOinstacron:UAEHenghttps://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/8526/9227info:eu-repo/semantics/openAccessoai:repository.uaeh.edu.mx:article/85262024-08-20T03:11:31Z
dc.title.none.fl_str_mv Intermittent fasting: a strategy to counteract aging linked to oxidative stress
Ayuno intermitente: una estrategia para contrarrestar el envejecimiento vinculado al estrés oxidativo
title Intermittent fasting: a strategy to counteract aging linked to oxidative stress
spellingShingle Intermittent fasting: a strategy to counteract aging linked to oxidative stress
Hidalgo-Silva , Diana
Autophagy
intermittent fasting
aging
oxidative stress
caloric restriction
Autofagia
ayuno intermitente
envejecimiento
estrés oxidativo
restricción calórica
title_short Intermittent fasting: a strategy to counteract aging linked to oxidative stress
title_full Intermittent fasting: a strategy to counteract aging linked to oxidative stress
title_fullStr Intermittent fasting: a strategy to counteract aging linked to oxidative stress
title_full_unstemmed Intermittent fasting: a strategy to counteract aging linked to oxidative stress
title_sort Intermittent fasting: a strategy to counteract aging linked to oxidative stress
dc.creator.none.fl_str_mv Hidalgo-Silva , Diana
López-Noguerola , José Sócrates
Sánchez-Gutiérrez , Manuel
Madrigal-Santillán , Eduardo Osiris
Izquierdo-Vega, Jeannett Alejandra
author Hidalgo-Silva , Diana
author_facet Hidalgo-Silva , Diana
López-Noguerola , José Sócrates
Sánchez-Gutiérrez , Manuel
Madrigal-Santillán , Eduardo Osiris
Izquierdo-Vega, Jeannett Alejandra
author_role author
author2 López-Noguerola , José Sócrates
Sánchez-Gutiérrez , Manuel
Madrigal-Santillán , Eduardo Osiris
Izquierdo-Vega, Jeannett Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv Autophagy
intermittent fasting
aging
oxidative stress
caloric restriction
Autofagia
ayuno intermitente
envejecimiento
estrés oxidativo
restricción calórica
topic Autophagy
intermittent fasting
aging
oxidative stress
caloric restriction
Autofagia
ayuno intermitente
envejecimiento
estrés oxidativo
restricción calórica
description Aging is a multifactorial deterioration process that occurs in the life of an organism, which seems to be linked to oxidative stress. Intermittent fasting (IF) consists of food restriction with intermediate periods of regular food intake repeatedly. Various studies in human beings and experimental animal models have shown that intermittent fasting counteracts various alterations associated with age and weight loss, a decrease in the concentration of insulin, glucose, and serum lipids, and oxidative stress, improving antioxidant defense. This review summarizes the evidence available to date in PubMed to analyze the effects of IF on the aging process and its link with oxidative stress. The results suggested that food restriction on alternate days and with a time restriction improves aging processes by decreasing oxidative stress markers and increasing autophagy related to longevity. IF represents a promising non-pharmacological alternative to improve health in the adult population. However, more studies are required to know the chronic effect of fasting and recognize its effects as a therapy in diseases associated with aging.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/8526
10.29057/mjmr.v10i20.8526
url https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/8526
identifier_str_mv 10.29057/mjmr.v10i20.8526
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/8526/9227
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Autónoma del Estado de Hidalgo
publisher.none.fl_str_mv Universidad Autónoma del Estado de Hidalgo
dc.source.none.fl_str_mv Mexican Journal of Medical Research ICSA; Vol 10 No 20 (2022): Mexican Journal of Medical Research ICSA; 16-24
Mexican Journal of Medical Research ICSA; Vol. 10 Núm. 20 (2022): Mexican Journal of Medical Research ICSA; 16-24
2007-5235
10.29057/mjmr.v10i20
reponame:Mexican Journal of Medical Research
instname:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
instacron:UAEH
instname_str UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
instacron_str UAEH
institution UAEH
reponame_str Mexican Journal of Medical Research
collection Mexican Journal of Medical Research
repository.name.fl_str_mv
repository.mail.fl_str_mv
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