Animal models to evaluate analgesic effects using isobolographic analysis

In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accu...

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Detalles Bibliográficos
Autor: Romero Molina, María Asunción
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:México
Institución:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
Repositorio:Mexican Journal of Medical Research
Idioma:inglés
OAI Identifier:oai:repository.uaeh.edu.mx:article/1751
Acceso en línea:https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/1751
Access Level:acceso abierto
Palabra clave:Animal models; Analgesic Effects; Drug combination; Isobolographic Analysis.
Descripción
Sumario:In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accurate design of the preclinical study is a requisite to obtain valid outcomes. Using the isobolographic analysis we can easily establish differences between synergistic or additive responses expected from drug combinations, improving the management and treatment of pain.