ASYMMETRIC TRANSFER HYDROGENATION OF KETONES IN AQUEOUS SOLUTION CATALYZED BY RHODIUM (III) COMPLEXES WITH C2-SYMMETRIC FLUORENE-LIGANDS CONTAINING CHIRAL (1R, 2R)-CYCLOHEXANE-1, 2-DIAMINE
Two C2-symmetric bis(sulfonamide) ligands containing fluorene-chiral (1R,2R)-cyclohexane-1,2-diamine were complexed to RhIII(Cp*) and used as catalyst to reduce aromatic ketones. The corresponding chiral secondary alcohols were obtained in 87-100% ee and 85-99% yield, under asymmetric transfer hydro...
| Autores: | , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | México |
| Recursos: | Universidad Autónoma de Nayarit |
| Repositorio: | Repositorio Institucional Aramara de la UAN |
| Idioma: | inglés |
| OAI Identifier: | oai:dspace.uan.mx:123456789/1970 |
| Acesso em linha: | http://dx.doi.org/10.1590/S0103-50532010000300005 http://dspace.uan.mx:8080/jspui/handle/123456789/1970 |
| Access Level: | acceso abierto |
| Palavra-chave: | ligandos de bis(sulfonamida) complejos RhIII(Cp*) hidrogenación por transferencia asimétrica bis(sulfonamide) ligands RhIII(Cp*) complexes asymmetric transfer hydrogenation MEDICINA Y CIENCIAS DE LA SALUD [3] |
| Resumo: | Two C2-symmetric bis(sulfonamide) ligands containing fluorene-chiral (1R,2R)-cyclohexane-1,2-diamine were complexed to RhIII(Cp*) and used as catalyst to reduce aromatic ketones. The corresponding chiral secondary alcohols were obtained in 87-100% ee and 85-99% yield, under asymmetric transfer hydrogenation (ATH) conditions using aqueous sodium formate as the hydride source. With acetophenone, 94% ee and 86-97% yield was achieved with substrate/catalyst (S/C) ratio of 10,000. |
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