Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?
Abstract Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitam...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | México |
| Institución: | Instituto Nacional de Salud Pública |
| Repositorio: | Repositorio Institucional Abierto de Conocimiento en Salud Pública |
| Idioma: | español |
| OAI Identifier: | oai:repositorio.insp.mx:20.500.12096/8207 |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551079/pdf/nutrients-12-02517.pdf https://www.doi.org/ 10.3390/nu12092517 http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8207 |
| Access Level: | acceso abierto |
| Palabra clave: | Cholecalciferol , administration dosage, Cohort Studies Dietary Supplements, Female Humans Maternal Nutritional Physiological Phenomena , physiology, Mexico , epidemiology Nutritional Requirements, Obesity, Maternal , metabolism, Pregnancy Pregnancy Complications , diet therapy, Pregnancy Complications , epidemiology Pregnancy Complications , prevention control, Pregnant Women, Prevalence Vitamin D , analogs derivatives Vitamin D , blood Vitamin D Deficiency , diet therapy, Vitamin D Deficiency , epidemiology Vitamin D Deficiency , prevention control, info:eu-repo/classification/cti/3 |
| Sumario: | Abstract Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017-2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0-250, 250-400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (20 and 30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72-8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250-400 IU/day were insufficient for achieving an adequate maternal vitamin D status. |
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