Dynamic infrared thermography of nanoheaters embedded in skin-equivalent phantoms
"Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable bec...
| Autores: | , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | México |
| Recursos: | Instituto Potosino de Investigación Científica y Tecnológica |
| Repositorio: | Repositorio Institucional del IPICYT |
| OAI Identifier: | oai:ipicyt.repositorioinstitucional.mx:1010/1856 |
| Acesso em linha: | http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1856 |
| Access Level: | acceso abierto |
| Palavra-chave: | info:eu-repo/classification/Autor/Gold nanoparticles info:eu-repo/classification/Autor/In-vivo info:eu-repo/classification/Autor/Photothermal therapy info:eu-repo/classification/Autor/Drug-delivery info:eu-repo/classification/Autor/Hepes buffer info:eu-repo/classification/Autor/Nanomaterials info:eu-repo/classification/Autor/Nanostars info:eu-repo/classification/Autor/Cancer info:eu-repo/classification/Autor/Seed info:eu-repo/classification/Autor/Nanocrystals info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/33 |
| Resumo: | "Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable because of the electromagnetic field concentrated at their vertices. We standardized a protocol to synthesize multibranched gold nanoparticles (MB-AuNPs) by the seed-growth method and found a size-seed dependence tunability on the hierarchy of branching. Once the optical response is evaluated, we tested the temporal stability as nanoheaters of the MB-AuNPs immersed in skin-equivalent phantoms by dynamic infrared thermography (DIRT). The most suited sample presents a concentration of 5.2 x 10(8) MB-AuNPs/mL showing good thermal stability with Delta T = 4.5 degrees C, during 3 cycles of 10 min at 785 nm laser irradiation with power of 0.15 W. According to these results, the MB-AuNPs are suitable nanoheaters to be tested for PTT in more complex models." |
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