Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico

Abstract Background: Occupational studies have shown an association between elevated Mn exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due to mobilization from tissues, suggesting it could contribute to pregnancy and postpartum depressive symptoms. Objectives: To a...

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Detalhes bibliográficos
Autores: Schnaas, Lourdes, Solano González, Maritsa, Tamayo Ortiz, Marcela, Téllez Rojo, Martha María
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Recursos:Instituto Nacional de Salud Pública
Repositorio:Repositorio Institucional Abierto de Conocimiento en Salud Pública
Idioma:español
OAI Identifier:oai:repositorio.insp.mx:20.500.12096/8199
Acesso em linha:https://reader.elsevier.com/reader/sd/pii/S0161813X19301329?token=0411748FEA0F2F4CB8539E30E5211037EDB2D60A3C5D0900BC6820A2E088AD9DCF3E05835DF264117C44E5241F359BE3&originRegion=us-east-1&originCreation=20221202172153
https://www.doi.org/10.1016/j.neuro.2019.11.005
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8199
Access Level:acceso abierto
Palavra-chave:Adult Cohort Studies Depression, Postpartum , blood, Depression, Postpartum , epidemiology Female Humans Manganese , blood, Mexico Psychiatric Status Rating Scales
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spelling Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in MexicoSchnaas, LourdesSolano González, MaritsaTamayo Ortiz, MarcelaTéllez Rojo, Martha MaríaAdult Cohort Studies Depression, Postpartum , blood, Depression, Postpartum , epidemiology Female Humans Manganese , blood, Mexico Psychiatric Status Rating Scalesinfo:eu-repo/classification/cti/3Abstract Background: Occupational studies have shown an association between elevated Mn exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due to mobilization from tissues, suggesting it could contribute to pregnancy and postpartum depressive symptoms. Objectives: To assess the association between BMn levels during pregnancy and postpartum depression (PPD), creating opportunities for possible future interventions. Methods: We studied 561 women from the reproductive longitudinal Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) cohort in Mexico City. BMn was measured at the 2nd and 3rd trimesters, as well as delivery. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD symptoms at 12-months postpartum. We used a generalized linear model assuming a Poisson distribution to assess the association between BMn levels and PPD, with adjustments for age, stress and depressive symptoms during pregnancy, education, socioeconomic status, and contemporaneous blood lead levels. Results: The mean ± standard deviation (SD) EPDS score at 12-months postpartum was 6.51 ± 5.65, and 17.11% of women met the criteria for possible PPD (score ≥ 13). In adjusted models, BMn during the 3rd trimester (β: 0.13, 95% CI: 0.04-0.21) and BMn levels averaged at the 2nd and 3rd trimester (β: 0.14, 95% CI: 0.02-0.26) had a positive association with EPDS scores at 12 months postpartum. BMn at the 2nd trimester (β: 0.07, 95% CI: -0.09-0.22) and delivery (β: 0.03, 95% CI: -0.04-0.10) had a non-significant positive association with EPDS scores at 12-months postpartum. Stress and depressive symptoms during pregnancy was associated with higher EPDS scores at 12-months postpartum in all of the adjusted models but were only significant when either BMn during 3rd trimester or BMn averaged across 2nd and 3rd trimester was assessed as the exposure. Discussion: Our results demonstrate that elevated BMn levels during pregnancy predict PPD symptoms and could be a potential pathway for intervention and prevention of PPD.ESPM INSP2023-05-25T14:21:22Z2023-05-25T14:21:22Z2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpdfsicabi.insp.mx:2020-Nonehttps://reader.elsevier.com/reader/sd/pii/S0161813X19301329?token=0411748FEA0F2F4CB8539E30E5211037EDB2D60A3C5D0900BC6820A2E088AD9DCF3E05835DF264117C44E5241F359BE3&originRegion=us-east-1&originCreation=20221202172153https://www.doi.org/10.1016/j.neuro.2019.11.005http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8199reponame:Repositorio Institucional Abierto de Conocimiento en Salud Públicainstname:Instituto Nacional de Salud Públicainstacron:INSPspanacionalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0oai:repositorio.insp.mx:20.500.12096/81992024-08-27T22:04:40Z
dc.title.none.fl_str_mv Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
title Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
spellingShingle Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
Schnaas, Lourdes
Adult Cohort Studies Depression, Postpartum , blood, Depression, Postpartum , epidemiology Female Humans Manganese , blood, Mexico Psychiatric Status Rating Scales
info:eu-repo/classification/cti/3
title_short Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
title_full Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
title_fullStr Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
title_full_unstemmed Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
title_sort Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico
dc.creator.none.fl_str_mv Schnaas, Lourdes
Solano González, Maritsa
Tamayo Ortiz, Marcela
Téllez Rojo, Martha María
author Schnaas, Lourdes
author_facet Schnaas, Lourdes
Solano González, Maritsa
Tamayo Ortiz, Marcela
Téllez Rojo, Martha María
author_role author
author2 Solano González, Maritsa
Tamayo Ortiz, Marcela
Téllez Rojo, Martha María
author2_role author
author
author
dc.subject.none.fl_str_mv Adult Cohort Studies Depression, Postpartum , blood, Depression, Postpartum , epidemiology Female Humans Manganese , blood, Mexico Psychiatric Status Rating Scales
info:eu-repo/classification/cti/3
topic Adult Cohort Studies Depression, Postpartum , blood, Depression, Postpartum , epidemiology Female Humans Manganese , blood, Mexico Psychiatric Status Rating Scales
info:eu-repo/classification/cti/3
description Abstract Background: Occupational studies have shown an association between elevated Mn exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due to mobilization from tissues, suggesting it could contribute to pregnancy and postpartum depressive symptoms. Objectives: To assess the association between BMn levels during pregnancy and postpartum depression (PPD), creating opportunities for possible future interventions. Methods: We studied 561 women from the reproductive longitudinal Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) cohort in Mexico City. BMn was measured at the 2nd and 3rd trimesters, as well as delivery. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD symptoms at 12-months postpartum. We used a generalized linear model assuming a Poisson distribution to assess the association between BMn levels and PPD, with adjustments for age, stress and depressive symptoms during pregnancy, education, socioeconomic status, and contemporaneous blood lead levels. Results: The mean ± standard deviation (SD) EPDS score at 12-months postpartum was 6.51 ± 5.65, and 17.11% of women met the criteria for possible PPD (score ≥ 13). In adjusted models, BMn during the 3rd trimester (β: 0.13, 95% CI: 0.04-0.21) and BMn levels averaged at the 2nd and 3rd trimester (β: 0.14, 95% CI: 0.02-0.26) had a positive association with EPDS scores at 12 months postpartum. BMn at the 2nd trimester (β: 0.07, 95% CI: -0.09-0.22) and delivery (β: 0.03, 95% CI: -0.04-0.10) had a non-significant positive association with EPDS scores at 12-months postpartum. Stress and depressive symptoms during pregnancy was associated with higher EPDS scores at 12-months postpartum in all of the adjusted models but were only significant when either BMn during 3rd trimester or BMn averaged across 2nd and 3rd trimester was assessed as the exposure. Discussion: Our results demonstrate that elevated BMn levels during pregnancy predict PPD symptoms and could be a potential pathway for intervention and prevention of PPD.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023-05-25T14:21:22Z
2023-05-25T14:21:22Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv sicabi.insp.mx:2020-None
https://reader.elsevier.com/reader/sd/pii/S0161813X19301329?token=0411748FEA0F2F4CB8539E30E5211037EDB2D60A3C5D0900BC6820A2E088AD9DCF3E05835DF264117C44E5241F359BE3&originRegion=us-east-1&originCreation=20221202172153
https://www.doi.org/10.1016/j.neuro.2019.11.005
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8199
identifier_str_mv sicabi.insp.mx:2020-None
url https://reader.elsevier.com/reader/sd/pii/S0161813X19301329?token=0411748FEA0F2F4CB8539E30E5211037EDB2D60A3C5D0900BC6820A2E088AD9DCF3E05835DF264117C44E5241F359BE3&originRegion=us-east-1&originCreation=20221202172153
https://www.doi.org/10.1016/j.neuro.2019.11.005
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8199
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv ESPM INSP
publisher.none.fl_str_mv ESPM INSP
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