JNK isoforms control mammal adult hippocampal neurogenesis

In mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by a population of immature neurons located in th...

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Detalhes bibliográficos
Autores: Auladell, Carme, Castro-Torres , Rubén D., Busquets, Oriol, Ettcheto, Miren, Camins, Antoni, Verdaguer, Ester
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Recursos:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
Repositorio:Mexican Journal of Medical Research
Idioma:inglés
OAI Identifier:oai:repository.uaeh.edu.mx:article/5548
Acesso em linha:https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/5548
Access Level:acceso abierto
Palavra-chave:JNK
isoforms
neurogenesis
hippocampus
JNK-pathway
JNK-isoforms
adult-neurogenesis
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spelling JNK isoforms control mammal adult hippocampal neurogenesisLas isoformas JNK controlan la actividad neurogénica hipocampal adulta en mamíferosAuladell, CarmeCastro-Torres , Rubén D. Busquets, Oriol Ettcheto, Miren Camins, Antoni Verdaguer, Ester JNKisoformsneurogenesishippocampusJNK-pathwayJNK-isoformshippocampusadult-neurogenesisIn mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by a population of immature neurons located in the SGZ. Either way, the existence of neurogenic activity in the hippocampus has been correlated with learning, memory formation and behavioral responses to stress, together with the pathophysiology of many brain diseases and mood disorders. Various extracellular and intracellular stimuli have been shown to modulate survival, proliferation, and differentiation of adult-born cells in the hippocampus especially, through conserved stimuli-response mechanisms like the JNKs, which have been described as regulators of adult neurogenesis. In the present review, the JNK pathway and their control of adult hippocampal neurogenesis is described, evidencing the critical role of JNK1 in this process.En mamíferos, “la neurogénesis hipocampal adulta”, se define como el proceso a través del cual, en adultos, se producen nuevas neuronas granulares a partir de células madre que se ubican en la zona subgranular (ZSG) del giro dentado del hipocampo o, por una población de neuronas inmaduras no procedentes del neuroepitelio embrionario y situadas en la ZSG. Sin importar su origen, la existencia de una actividad neurogénica en el hipocampo adulto se ha correlacionado con el aprendizaje, la formación de memoria y en el comportamiento ante situaciones de estrés. Asimismo, su control es crítico en diferentes patologías del cerebro, incluso en casos de alteraciones del estado de ánimo. Se ha demostrado que diferentes estímulos extracelulares e intracelulares controlan la supervivencia, la proliferación y la diferenciación de las nuevas neuronas del hipocampo, especialmente a través de mecanismos conservados de respuesta a estímulos como las JNKs, las cuales han sido descritas como reguladoras de la neurogénesis adulta. En la presente revisión se describe la relación de la vía de JNK y su control de la neurogénesis hipocampal adulta, evidenciando el papel crucial de la forma JNK1.Universidad Autónoma del Estado de Hidalgo2020-07-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/554810.29057/mjmr.v8i16.5548Mexican Journal of Medical Research ICSA; Vol 8 No 16 (2020): Mexican Journal of Medical Research ICSA; 5-12Mexican Journal of Medical Research ICSA; Vol. 8 Núm. 16 (2020): Mexican Journal of Medical Research ICSA; 5-122007-523510.29057/mjmr.v8i16reponame:Mexican Journal of Medical Researchinstname:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGOinstacron:UAEHenghttps://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/5548/7310info:eu-repo/semantics/openAccessoai:repository.uaeh.edu.mx:article/55482024-08-20T03:11:30Z
dc.title.none.fl_str_mv JNK isoforms control mammal adult hippocampal neurogenesis
Las isoformas JNK controlan la actividad neurogénica hipocampal adulta en mamíferos
title JNK isoforms control mammal adult hippocampal neurogenesis
spellingShingle JNK isoforms control mammal adult hippocampal neurogenesis
Auladell, Carme
JNK
isoforms
neurogenesis
hippocampus
JNK-pathway
JNK-isoforms
hippocampus
adult-neurogenesis
title_short JNK isoforms control mammal adult hippocampal neurogenesis
title_full JNK isoforms control mammal adult hippocampal neurogenesis
title_fullStr JNK isoforms control mammal adult hippocampal neurogenesis
title_full_unstemmed JNK isoforms control mammal adult hippocampal neurogenesis
title_sort JNK isoforms control mammal adult hippocampal neurogenesis
dc.creator.none.fl_str_mv Auladell, Carme
Castro-Torres , Rubén D.
Busquets, Oriol
Ettcheto, Miren
Camins, Antoni
Verdaguer, Ester
author Auladell, Carme
author_facet Auladell, Carme
Castro-Torres , Rubén D.
Busquets, Oriol
Ettcheto, Miren
Camins, Antoni
Verdaguer, Ester
author_role author
author2 Castro-Torres , Rubén D.
Busquets, Oriol
Ettcheto, Miren
Camins, Antoni
Verdaguer, Ester
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv JNK
isoforms
neurogenesis
hippocampus
JNK-pathway
JNK-isoforms
hippocampus
adult-neurogenesis
topic JNK
isoforms
neurogenesis
hippocampus
JNK-pathway
JNK-isoforms
hippocampus
adult-neurogenesis
description In mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by a population of immature neurons located in the SGZ. Either way, the existence of neurogenic activity in the hippocampus has been correlated with learning, memory formation and behavioral responses to stress, together with the pathophysiology of many brain diseases and mood disorders. Various extracellular and intracellular stimuli have been shown to modulate survival, proliferation, and differentiation of adult-born cells in the hippocampus especially, through conserved stimuli-response mechanisms like the JNKs, which have been described as regulators of adult neurogenesis. In the present review, the JNK pathway and their control of adult hippocampal neurogenesis is described, evidencing the critical role of JNK1 in this process.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/5548
10.29057/mjmr.v8i16.5548
url https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/5548
identifier_str_mv 10.29057/mjmr.v8i16.5548
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/5548/7310
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Autónoma del Estado de Hidalgo
publisher.none.fl_str_mv Universidad Autónoma del Estado de Hidalgo
dc.source.none.fl_str_mv Mexican Journal of Medical Research ICSA; Vol 8 No 16 (2020): Mexican Journal of Medical Research ICSA; 5-12
Mexican Journal of Medical Research ICSA; Vol. 8 Núm. 16 (2020): Mexican Journal of Medical Research ICSA; 5-12
2007-5235
10.29057/mjmr.v8i16
reponame:Mexican Journal of Medical Research
instname:UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
instacron:UAEH
instname_str UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO
instacron_str UAEH
institution UAEH
reponame_str Mexican Journal of Medical Research
collection Mexican Journal of Medical Research
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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