Impacto del tratamiento periodontal no quirúrgico en la concentración y nivel de MRP-8/14 (calprotectina) como biomarcador inflamatorio en mujeres con periodontitis y artritis reumatoide: un estudio cuasiexperimental.
Abstract: The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NSPT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasiexperimental stud...
| Autores: | , |
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | México |
| Institución: | Universidad Autónoma de San Luis Potosí |
| Repositorio: | Repositorio Institucional de la UASLP |
| OAI Identifier: | oai:repositorioinstitucional.uaslp.mx:i/8565 |
| Acceso en línea: | https://repositorioinstitucional.uaslp.mx/xmlui/handle/i/8565 |
| Access Level: | acceso abierto |
| Palabra clave: | Oral health Periodontitis Periodontal treatment Inflammatory biomarkers Rheumatoid arthritis Periodontitis (bvs) Salud bucal (bvs) Artritis reumatoide (bvs) MEDICINA Y CIENCIAS DE LA SALUD |
| Sumario: | Abstract: The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NSPT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasiexperimental study, we evaluated 30 women (mean age: 52.0 ± 5.8 years) with periodontitis and RA who had been diagnosed and treated for RA for more than 3 years and whose activity markers remained at similar values without significant reduction over three consecutive months. Patients underwent NS-PT, which included plaque control, scaling, and root planing. Serum and saliva samples, periodontal indices, RA activity markers, Disease Activity Score-28 (DAS28), the erythrocyte sedimentation rate (ESR), and the C-reactive protein (CRP) and CLP contents were measured at the beginning of the study and 6 and 12 weeks after NS-PT. Parametric and nonparametric tests were used in the analysis. The mean age was 52.0 ± 5.8 years. Compared to the baseline results, all periodontal indices were significantly reduced 6 and 12 weeks after NS-PT (p < 0.001). DAS28 was also significantly reduced after 12 weeks (p < 0.0001). Similarly, the serum CLP concentration decreased 6 and 12 weeks after NS-PT (p < 0.0001). Of the patients, 100% presented lower levels of CRP and ESR (p < 0.0001). Overall, NS-PT reduced inflammation and disease activity, highlighting the importance of oral health in the control and treatment of systemic diseases such as RA and confirming that NS-PT effectively reduces periodontitis activity and plays a key role in modulating RA activity. Therefore, NS-PT should be considered as an adjunct treatment for RA. |
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