Streptococcus pneumoniae Serotype 3 in Mexico (1994 to 2017): Decrease of the Unusual Clonal Complex 4909 Lineage following PCV13 Introduction
Streptococcus pneumoniae expressing serotype 3 has a high virulence and a high case fatality ratio. Most studies of serotype 3 pneumococci have focused on a single lineage, the widespread sequence type 180 (ST180). To evaluate the serotype 3 lineages causing infections in Mexico, we characterized 19...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | México |
| Institución: | Instituto Nacional de Salud Pública |
| Repositorio: | Repositorio Institucional Abierto de Conocimiento en Salud Pública |
| Idioma: | español |
| OAI Identifier: | oai:repositorio.insp.mx:20.500.12096/7804 |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322463/pdf/JCM.01354-18.pdf https://www.doi.org/10.1128/JCM.01354-18. http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/7804 |
| Access Level: | acceso abierto |
| Palabra clave: | AdolescentAdultAgedAnti-Bacterial Agents pharmacologyChildChild, PreschoolDrug Resistance, BacterialEpidemiological MonitoringFemaleGenome, Bacterial geneticsHumansInfantInfant, NewbornMaleMexico epidemiologyMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingPneumococcal Infections epidemiology,Pneumococcal Infections microbiology,Pneumococcal Infections prevention controlPneumococcal Vaccines administration dosageSerogroupSerotypingStreptococcus pneumoniae classificationStreptococcus pneumoniae drug effectsStreptococcus pneumoniae geneticsYoung Adult,SD info:eu-repo/classification/cti/3 |
| Sumario: | Streptococcus pneumoniae expressing serotype 3 has a high virulence and a high case fatality ratio. Most studies of serotype 3 pneumococci have focused on a single lineage, the widespread sequence type 180 (ST180). To evaluate the serotype 3 lineages causing infections in Mexico, we characterized 196 isolates recovered from 1994 to 2017. The isolates were mostly susceptible to all antimicrobials tested. A single meningitis isolate was resistant to penicillin, and the resistance to erythromycin was 5.2%. The isolates represented the widely disseminated clonal complex 180 (CC180; n = 140), the unusual CC4909 (n = 42), CC260 (n = 11), and a few singletons (n = 3). CC260 was less frequent among pneumococcal invasive disease isolates than CC180 and CC4909 (P = 0.015). There was a decrease of CC4909 (P 0.001) following PCV13 introduction (2012 to 2017). The CC4909 isolates were represented mostly by ST1119 (n = 40), seemingly having a restricted geographic origin, with isolates in the PubMLST database having been recovered only in Mexico, the United States, and Germany. A genomic analysis of publicly available genomes showed that ST1119 isolates have less than 32% similarity with ST180 isolates, indicating that these lineages are more separated than revealed by traditional multilocus sequence typing. Considering the suggestions of a lower efficacy of the 13-valent pneumococcal conjugate vaccine against serotype 3, the different dynamics of the two major serotype 3 lineages in Mexico following the introduction of PCV13 should be closely monitored |
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