Dysregulation in hepatic cholesterol homeostasis and its implications in nonalcoholic steatohepatitis
Several studies have shown that hepatic free cholesterol (FC) has an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). These studies have provided evidence that hepatic FC accumulation is toxic at different levels including: mitochondrial oxidative injury, endoplasmic reticu...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | México |
| Institución: | UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO |
| Repositorio: | TIP Revista especializada en ciencias químico-biológicas |
| Idioma: | español |
| OAI Identifier: | oai:ojs.ojs.escire.net:article/119 |
| Acceso en línea: | http://tip.zaragoza.unam.mx/index.php/tip/article/view/119 |
| Access Level: | acceso abierto |
| Palabra clave: | free cholesterol; NASH; fibrosis; NAFLD; homeostasis colesterol libre; EHNA; fibrosis; HGNA; homeostasis |
| Sumario: | Several studies have shown that hepatic free cholesterol (FC) has an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). These studies have provided evidence that hepatic FC accumulation is toxic at different levels including: mitochondrial oxidative injury, endoplasmic reticulum (ER) stress, and activation of Kupffer cells (KCs) and hepatic stellate cell (HSCs). Altogether, this suggests that hepatic FC content is important for the initiation, maintenance and modulation of the inflammatory response associated with NASH. In this review several mechanisms that participate in the regulation of cholesterol homeostasis and their possible implications in the development and progression of nonalcoholic fatty liver disease (NAFLD) are discussed. |
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