The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia

Objective To evaluate whether the maternal, paternal or the combined maternal/paternal contribution of SNP rs5370 of the EDN1 gene is associated with preeclampsia and drove its expression in placenta. Study design This case-control study included 61 preeclamptic patients and their partners and 49 he...

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Autores: Galaviz Hernandez, Carlos, Arámbula Meraz, Eliakym, Medina Bastidas, Diana, Sosa Macías, Martha, Lazalde Ramos, Blanca Patricia, Ortega Chávez, Margarita, Hernandez García, Lorena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:México
Institución:Universidad Autónoma de Zacatecas
Repositorio:Repositorio Institucional Caxcán
Idioma:inglés
OAI Identifier:oai:http://ricaxcan.uaz.edu.mx:20.500.11845/2660
Acceso en línea:http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2660
https://doi.org/10.48779/3h4n-m815
Access Level:acceso abierto
Palabra clave:BIOLOGIA Y QUIMICA [2]
Preeclampsia
Paternal
Polymorphism
EDN1
Placenta
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spelling The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsiaGalaviz Hernandez, CarlosArámbula Meraz, EliakymMedina Bastidas, DianaSosa Macías, MarthaLazalde Ramos, Blanca PatriciaOrtega Chávez, MargaritaHernandez García, LorenaBIOLOGIA Y QUIMICA [2]PreeclampsiaPaternalPolymorphismEDN1PlacentaObjective To evaluate whether the maternal, paternal or the combined maternal/paternal contribution of SNP rs5370 of the EDN1 gene is associated with preeclampsia and drove its expression in placenta. Study design This case-control study included 61 preeclamptic patients and their partners and 49 healthy pregnant women and their partners. The population was sub-divided into three groups: women-only, men-only and combined (women/men). The analysis included genotyping of rs5370 in mothers and fathers and evaluating the expression profile of the EDN1 gene in placenta. Comparisons of categorical variables were performed using chi-square and/or Fisher’s exact tests. The intergroup comparisons were analysed with the Mann-Whitney U test. The association between the polymorphism and the disease was evaluated through multivariate regression analysis. Spearman’s correlation was performed to test the relationship between pre-gestational history and clinical features of the affected patients with EDN1 gene expression. Results The analysis of paternal risk factors associated with preeclampsia revealed no differences between groups. A negative association between SNP rs5370 and preeclampsia was found in men group (OR 0.42; CI 95% 0.18–0.94, p = 0.034) but not in women or combined groups. The adjustment for paternal protective factors increased the observed negative association, and the opposite was observed in the presence of paternal risk factors. The expression of the EDN1 gene in the placenta was significantly higher in the group of cases and was not associated with the rs5370 polymorphism. Conclusion The paternal rs5370 polymorphism decreases the risk for preeclampsia and is not associated with placental expression of the EDN1 gene.Elsevierhttps://orcid.org/0000-0002-1995-1696464612021-06-25T00:07:58Z2021-06-25T00:07:58Z2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionimage/pnginfo:eu-repo/semantics/publishedVersion2210-7789http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2660https://doi.org/10.48779/3h4n-m815Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health Vol. 6, No. 4, pp. 327-332reponame:Repositorio Institucional Caxcáninstname:Universidad Autónoma de Zacatecasinstacron:UAZenghttps://www.sciencedirect.com/science/article/abs/pii/S2210778916300150?via%3DihubgeneralPublicGlobalAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de Américahttp://creativecommons.org/licenses/by-nc-sa/3.0/us/info:eu-repo/semantics/openAccessoai:http://ricaxcan.uaz.edu.mx:20.500.11845/26602024-08-28T03:21:28Z
dc.title.none.fl_str_mv The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
title The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
spellingShingle The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
Galaviz Hernandez, Carlos
BIOLOGIA Y QUIMICA [2]
Preeclampsia
Paternal
Polymorphism
EDN1
Placenta
title_short The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
title_full The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
title_fullStr The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
title_full_unstemmed The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
title_sort The paternal polymorphism rs5370 in the EDN1 gene decreases the risk of preeclampsia
dc.creator.none.fl_str_mv Galaviz Hernandez, Carlos
Arámbula Meraz, Eliakym
Medina Bastidas, Diana
Sosa Macías, Martha
Lazalde Ramos, Blanca Patricia
Ortega Chávez, Margarita
Hernandez García, Lorena
author Galaviz Hernandez, Carlos
author_facet Galaviz Hernandez, Carlos
Arámbula Meraz, Eliakym
Medina Bastidas, Diana
Sosa Macías, Martha
Lazalde Ramos, Blanca Patricia
Ortega Chávez, Margarita
Hernandez García, Lorena
author_role author
author2 Arámbula Meraz, Eliakym
Medina Bastidas, Diana
Sosa Macías, Martha
Lazalde Ramos, Blanca Patricia
Ortega Chávez, Margarita
Hernandez García, Lorena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv https://orcid.org/0000-0002-1995-1696
46461
dc.subject.none.fl_str_mv BIOLOGIA Y QUIMICA [2]
Preeclampsia
Paternal
Polymorphism
EDN1
Placenta
topic BIOLOGIA Y QUIMICA [2]
Preeclampsia
Paternal
Polymorphism
EDN1
Placenta
description Objective To evaluate whether the maternal, paternal or the combined maternal/paternal contribution of SNP rs5370 of the EDN1 gene is associated with preeclampsia and drove its expression in placenta. Study design This case-control study included 61 preeclamptic patients and their partners and 49 healthy pregnant women and their partners. The population was sub-divided into three groups: women-only, men-only and combined (women/men). The analysis included genotyping of rs5370 in mothers and fathers and evaluating the expression profile of the EDN1 gene in placenta. Comparisons of categorical variables were performed using chi-square and/or Fisher’s exact tests. The intergroup comparisons were analysed with the Mann-Whitney U test. The association between the polymorphism and the disease was evaluated through multivariate regression analysis. Spearman’s correlation was performed to test the relationship between pre-gestational history and clinical features of the affected patients with EDN1 gene expression. Results The analysis of paternal risk factors associated with preeclampsia revealed no differences between groups. A negative association between SNP rs5370 and preeclampsia was found in men group (OR 0.42; CI 95% 0.18–0.94, p = 0.034) but not in women or combined groups. The adjustment for paternal protective factors increased the observed negative association, and the opposite was observed in the presence of paternal risk factors. The expression of the EDN1 gene in the placenta was significantly higher in the group of cases and was not associated with the rs5370 polymorphism. Conclusion The paternal rs5370 polymorphism decreases the risk for preeclampsia and is not associated with placental expression of the EDN1 gene.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
2021-06-25T00:07:58Z
2021-06-25T00:07:58Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv info:eu-repo/semantics/publishedVersion
2210-7789
http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2660
https://doi.org/10.48779/3h4n-m815
identifier_str_mv info:eu-repo/semantics/publishedVersion
2210-7789
url http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2660
https://doi.org/10.48779/3h4n-m815
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S2210778916300150?via%3Dihub
generalPublic
dc.rights.none.fl_str_mv Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv image/png
dc.coverage.none.fl_str_mv Global
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health Vol. 6, No. 4, pp. 327-332
reponame:Repositorio Institucional Caxcán
instname:Universidad Autónoma de Zacatecas
instacron:UAZ
instname_str Universidad Autónoma de Zacatecas
instacron_str UAZ
institution UAZ
reponame_str Repositorio Institucional Caxcán
collection Repositorio Institucional Caxcán
repository.name.fl_str_mv
repository.mail.fl_str_mv
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