Evaluation of dopamine d4 receptors blockade in the nucleus accumbens on motivation for palatable food
At the central level, regulation of information processing of the motivational and reinforcing properties of food depends principally on brain structures such as the nucleus accumbens shell (NAcS), where dopaminergic transmission plays a preponderant role in activating dopamine receptors related to...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | México |
| Institución: | UNIVERSIDAD AUTÓNOMA DE CHIAPAS |
| Repositorio: | Revista Espacio I+D Innovación más Desarrollo |
| Idioma: | español inglés |
| OAI Identifier: | oai:ojs.espacioimasd.unach.mx:article/201 |
| Acceso en línea: | https://www.espacioimasd.unach.mx/index.php/Inicio/article/view/201 |
| Access Level: | acceso abierto |
| Palabra clave: | Núcleo Accumbens Shell Receptor D4 dopaminérgico L-745,870 Motivación Alimento palatable Nucleus Accumbens Shell Dopamine D4 receptor Motivation palatable food |
| Sumario: | At the central level, regulation of information processing of the motivational and reinforcing properties of food depends principally on brain structures such as the nucleus accumbens shell (NAcS), where dopaminergic transmission plays a preponderant role in activating dopamine receptors related to reward. Anatomical and neurochemical studies indicate that D4 dopamine receptors (D4R) are presynaptically expressed and regulate the release of glutamate to GABAergic neurons in the NAcS. The purpose of this study was to evaluate the effects of the pharmacological blockade of D4R in the NAcS on the regulation of motivation for palatable food (MPF) in male Sprague Dawley rats using a progressive ratio (PR) reinforcement program. According to our results, blockade of the RD4 with the antagonist, L-745,870 (1 µg), in the NAcS decreases the number of levers presses, the number of reinforcers obtained and the breakpoints. Accordingly, the blockade of RD4 in the NAcS decreases the MPF, so it could be a pharmacological target in the treatment of feeding pathology by decreasing the reinforcing properties of palatable food. |
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