Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids

Epistasis strongly affects the performance of superior maize hybrids. In this study, a multiple-hybrid population, consisting of three hybrid maize sets with varied interparental divergence, was generated by crossing 28 temperate and 23 tropical inbred lines with diverse genetic backgrounds. We obta...

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Detalles Bibliográficos
Autores: Zhiqin Sang, Hui Wang, Yuxin Yang, Zhanqin Zhang, Xiaogang Liu, Zhiwei Li, Yunbi Xu
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:México
Institución:Centro Internacional de Mejoramiento de Maíz y Trigo
Repositorio:Repositorio Institucional de Publicaciones Multimedia del CIMMYT
OAI Identifier:oai:repository.cimmyt.org:10883/22142
Acceso en línea:https://hdl.handle.net/10883/22142
Access Level:acceso abierto
Palabra clave:AGRICULTURAL SCIENCES AND BIOTECHNOLOGY
Genome-Wide Association Study
Epistatic Effects
Protein Interaction
Multiple-Hybrid Population
HETEROSIS
MAIZE
PROTEINS
HYBRIDS
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spelling Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybridsZhiqin SangHui WangYuxin YangZhanqin ZhangXiaogang LiuZhiwei LiYunbi XuAGRICULTURAL SCIENCES AND BIOTECHNOLOGYGenome-Wide Association StudyEpistatic EffectsProtein InteractionMultiple-Hybrid PopulationHETEROSISMAIZEPROTEINSHYBRIDSEpistasis strongly affects the performance of superior maize hybrids. In this study, a multiple-hybrid population, consisting of three hybrid maize sets with varied interparental divergence, was generated by crossing 28 temperate and 23 tropical inbred lines with diverse genetic backgrounds. We obtained 1,154 tested hybrids. Among these tested hybrids, heterosis increased steadily as the heterotic genetic distance increased. Mid-parent heterosis was significantly higher in the temperate by tropical hybrids than in the temperate by temperate hybrids. Genome-wide prediction and association mapping was performed for grain weight per plant (GWPP) and days to silking (DTS) using 20K high-quality SNPs, showing that epistatic effects played a more prominent role than dominance effects in temperate by tropical maize hybrids. A total of 33 and 420 epistatic QTL were identified for GWPP and DTS, respectively, in the temperate by tropical hybrids. Protein–protein interaction network and gene-set enrichment analyses showed that epistatic genes were involved in protein interactions, which play an important role in photosynthesis, biological transcription pathways, and protein synthesis. We showed that the interaction of many minor-effect genes in the hybrids could activate the transcription activators of epistatic genes, resulting in a cascade of amplified yield heterosis. The multiple-hybrid population design enhanced our understanding of heterosis in maize, providing an insight into the acceleration of hybrid maize breeding by activating epistatic effects.Frontiers Media S.A.2022-08-16T00:05:15Z2022-08-16T00:05:15Z2022Published Versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10883/2214210.3389/fpls.2022.921608131664-462XFrontiers in Plant Science921608reponame:Repositorio Institucional de Publicaciones Multimedia del CIMMYTinstname:Centro Internacional de Mejoramiento de Maíz y Trigoinstacron:CIMMYTEnglishhttps://figshare.com/collections/Epistasis_Activation_Contributes_Substantially_to_Heterosis_in_Temperate_by_Tropical_Maize_Hybrids/6088890SwitzerlandCIMMYT manages Intellectual Assets as International Public Goods. The user is free to download, print, store and share this work. In case you want to translate or create any other derivative work and share or distribute such translation/derivative work, please contact CIMMYT-Knowledge-Center@cgiar.org indicating the work you want to use and the kind of use you intend; CIMMYT will contact you with the suitable license for that purposeOpen Accessinfo:eu-repo/semantics/openAccessoai:repository.cimmyt.org:10883/221422024-10-11T19:56:06Z
dc.title.none.fl_str_mv Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
title Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
spellingShingle Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
Zhiqin Sang
AGRICULTURAL SCIENCES AND BIOTECHNOLOGY
Genome-Wide Association Study
Epistatic Effects
Protein Interaction
Multiple-Hybrid Population
HETEROSIS
MAIZE
PROTEINS
HYBRIDS
title_short Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
title_full Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
title_fullStr Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
title_full_unstemmed Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
title_sort Epistasis activation contributes substantially to heterosis in temperate by tropical maize hybrids
dc.creator.none.fl_str_mv Zhiqin Sang
Hui Wang
Yuxin Yang
Zhanqin Zhang
Xiaogang Liu
Zhiwei Li
Yunbi Xu
author Zhiqin Sang
author_facet Zhiqin Sang
Hui Wang
Yuxin Yang
Zhanqin Zhang
Xiaogang Liu
Zhiwei Li
Yunbi Xu
author_role author
author2 Hui Wang
Yuxin Yang
Zhanqin Zhang
Xiaogang Liu
Zhiwei Li
Yunbi Xu
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AGRICULTURAL SCIENCES AND BIOTECHNOLOGY
Genome-Wide Association Study
Epistatic Effects
Protein Interaction
Multiple-Hybrid Population
HETEROSIS
MAIZE
PROTEINS
HYBRIDS
topic AGRICULTURAL SCIENCES AND BIOTECHNOLOGY
Genome-Wide Association Study
Epistatic Effects
Protein Interaction
Multiple-Hybrid Population
HETEROSIS
MAIZE
PROTEINS
HYBRIDS
description Epistasis strongly affects the performance of superior maize hybrids. In this study, a multiple-hybrid population, consisting of three hybrid maize sets with varied interparental divergence, was generated by crossing 28 temperate and 23 tropical inbred lines with diverse genetic backgrounds. We obtained 1,154 tested hybrids. Among these tested hybrids, heterosis increased steadily as the heterotic genetic distance increased. Mid-parent heterosis was significantly higher in the temperate by tropical hybrids than in the temperate by temperate hybrids. Genome-wide prediction and association mapping was performed for grain weight per plant (GWPP) and days to silking (DTS) using 20K high-quality SNPs, showing that epistatic effects played a more prominent role than dominance effects in temperate by tropical maize hybrids. A total of 33 and 420 epistatic QTL were identified for GWPP and DTS, respectively, in the temperate by tropical hybrids. Protein–protein interaction network and gene-set enrichment analyses showed that epistatic genes were involved in protein interactions, which play an important role in photosynthesis, biological transcription pathways, and protein synthesis. We showed that the interaction of many minor-effect genes in the hybrids could activate the transcription activators of epistatic genes, resulting in a cascade of amplified yield heterosis. The multiple-hybrid population design enhanced our understanding of heterosis in maize, providing an insight into the acceleration of hybrid maize breeding by activating epistatic effects.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-16T00:05:15Z
2022-08-16T00:05:15Z
2022
dc.type.none.fl_str_mv Published Version
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10883/22142
10.3389/fpls.2022.921608
url https://hdl.handle.net/10883/22142
identifier_str_mv 10.3389/fpls.2022.921608
dc.language.none.fl_str_mv English
language_invalid_str_mv English
dc.relation.none.fl_str_mv https://figshare.com/collections/Epistasis_Activation_Contributes_Substantially_to_Heterosis_in_Temperate_by_Tropical_Maize_Hybrids/6088890
dc.rights.none.fl_str_mv Open Access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Open Access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Switzerland
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv 13
1664-462X
Frontiers in Plant Science
921608
reponame:Repositorio Institucional de Publicaciones Multimedia del CIMMYT
instname:Centro Internacional de Mejoramiento de Maíz y Trigo
instacron:CIMMYT
instname_str Centro Internacional de Mejoramiento de Maíz y Trigo
instacron_str CIMMYT
institution CIMMYT
reponame_str Repositorio Institucional de Publicaciones Multimedia del CIMMYT
collection Repositorio Institucional de Publicaciones Multimedia del CIMMYT
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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