Coumarin Derivatives from Loeselia mexicana. Determination of the Anxiolytic Effect of Daphnoretin on Elevated Plus-maze
The bis-coumarin daphnoretin (1) and its monomeric precursorsscopoletin (3) and umbelliferone (4) were isolated for the firsttime from L. mexicana, a vegetal species used in Mexican traditionalmedicine. The unambiguous 13C NMR chemical shifts assignmentsof daphnoretin (1) and its acetyl derivative 2...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | México |
| Institución: | Instituto Mexicano del Seguro Social |
| Repositorio: | Redalyc-IMSS |
| OAI Identifier: | oai:redalyc.org:47551405 |
| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=47551405 |
| Access Level: | acceso abierto |
| Palabra clave: | Química anxiety daphnoretin acetyldaphnoretin elevated plus maze 13C NMR chemical shift |
| Sumario: | The bis-coumarin daphnoretin (1) and its monomeric precursorsscopoletin (3) and umbelliferone (4) were isolated for the firsttime from L. mexicana, a vegetal species used in Mexican traditionalmedicine. The unambiguous 13C NMR chemical shifts assignmentsof daphnoretin (1) and its acetyl derivative 2 were achieved throughone-bond (gHMQC) and long-distance (gHMBC) heteronuclear correlations.The crude hydroalcoholic extract and pure daphnoretin 1obtained from this plant, showed anxiolytic effect in male ICR miceexposed to elevated plus-maze. Different doses of daphnoretin (1)were not able to modify the spontaneous locomotor activity measuredin the open field test. This is the first report regarding to the anxiolyticeffect of daphnoretin (1). |
|---|