Association of the 5HTTLPR Polymorphism with Obesity in Mexican Women with High Native American Ancestry

Aims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L- and S-alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) grou...

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Detalles Bibliográficos
Autores: Galaviz Hernández, Carlos, Lazalde Ramos, Blanca Patricia, Martínez Cortéz, Gabriela, Rangel Villalobos, Héctor, Martínez Aguilar, Gerardo, Leal Ugarte, Evelia, Peralta Leal, Valeria, González Rentería, Siblie, Rodríguez Moran, Martha, Jaquez Chairez, Francia, Guerrero Romero, Fernando, Sosa Macías, Martha
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Institución:Universidad Autónoma de Zacatecas
Repositorio:Repositorio Institucional Caxcán
Idioma:español
OAI Identifier:oai:http://ricaxcan.uaz.edu.mx:20.500.11845/2596
Acceso en línea:http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2596
https://doi.org/10.48779/365m-7j95
Access Level:acceso abierto
Palabra clave:BIOLOGIA Y QUIMICA [2]
Obesity
L- and S-alleles
5HTTLPR polymorphism
Descripción
Sumario:Aims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L- and S-alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) groups; 40 Mexican mestizos; and 33 Caucasian Mennonites were enrolled in a cross-sectional study. High (≥90%) and low (<90%) NA ancestry was molecularly determined. A body mass index >30 kg/m2 was considered as obese. The L- and S-alleles of the 5HTTLPR locus were identified by PCR; the association between alleles and obesity was performed by logistic regression analysis. Results: A significantly lower prevalence of obesity (35%) was observed in participants from communities with high NA ancestry (p < 0.005). Under a dominant heritance model the L-allele was associated with obesity in women with high NA ancestry (odds ratio [OR] 7.27; 95% confidence interval [CI] 1.6–32.5; p = 0.009) but not in women with low NA ancestry (OR 0.83; 95% CI 0.3–2.2; p = 0.71); no association was observed in men. Conclusion:Our results suggest that the 5HTTLPR L-allele is a risk factor for developing obesity in Mexican women with high NA ancestry (≥90%).

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