An integrative overview of the cannabinergic system and mental health

Background. The endocannabinoid system (eCBs) is one of the modulatory systems widely expressed in the brain. It consists of receptors expressed in the cytoplasmic (CB1 and CB2), the mitochondrial membrane (CB1), and the endogenous ligands known as endocannabinoids, such as anandamide, 2AG and oleam...

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Autores: Oscar E. Prospéro García, Pavel E. Rueda Orozco, Octavio Amancio Belmont, Alejandra E. Ruiz Contreras, Mónica Méndez Díaz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:México
Institución:Universidad Nacional Autónoma de México
Repositorio:Redalyc-UNAM
OAI Identifier:oai:redalyc.org:58251633005
Acceso en línea:https://www.redalyc.org/articulo.oa?id=58251633005
https://www.redalyc.org/journal/582/58251633005/
https://www.redalyc.org/journal/582/58251633005/html/
https://www.redalyc.org/journal/582/58251633005/58251633005.epub
https://www.redalyc.org/journal/582/58251633005/movil
Access Level:acceso abierto
Palabra clave:Medicina
mental health
endocannabinoids
Cannabinoid system
cannabinoid receptor 1
cannabinoid receptor 2
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spelling An integrative overview of the cannabinergic system and mental healthOscar E. Prospéro GarcíaPavel E. Rueda OrozcoOctavio Amancio BelmontAlejandra E. Ruiz ContrerasMónica Méndez DíazMedicinamental healthendocannabinoidsCannabinoid systemcannabinoid receptor 1cannabinoid receptor 2Background. The endocannabinoid system (eCBs) is one of the modulatory systems widely expressed in the brain. It consists of receptors expressed in the cytoplasmic (CB1 and CB2), the mitochondrial membrane (CB1), and the endogenous ligands known as endocannabinoids, such as anandamide, 2AG and oleam - ide. CB1 has been found in excitatory and inhibitory neurons in the pre- and post-synaptic membranes. It is expressed in several brain areas such as the hippocampus, dorsal, and ventral striatum, amygdala and prefrontal cortex. The eCBs has been involved in the regulation of learning and memory, mood, energy bal- ance, sleep, and drug addiction. Objective. Integrate existing information about the eCBs and its role in brain function and mental health. Method. Review of the information of basic and clinical relevance obtained from indexed scientific journals (PubMed/Medline, Scopus). Results. Basic and clinical research on eCBs related to central nervous system function is described. Discussion and conclusion. At present, the study of eCBs is of importance. The development of drugs that affect this system may be clinically useful to control different debilitating diseases. This is an area of interest to the scientific community and health care providers.Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf0185-3325https://www.redalyc.org/articulo.oa?id=58251633005https://www.redalyc.org/journal/582/58251633005/https://www.redalyc.org/journal/582/58251633005/html/https://www.redalyc.org/journal/582/58251633005/58251633005.epubhttps://www.redalyc.org/journal/582/58251633005/movilSalud Mental (México) Num.3 Vol.40reponame:Redalyc-UNAMinstname:Universidad Nacional Autónoma de Méxicoinstacron:UNAMenhttp://www.redalyc.org/revista.oa?id=582Salud Mentalinfo:eu-repo/semantics/openAccessoai:redalyc.org:582516330052025-09-03T18:06:32Z
dc.title.none.fl_str_mv An integrative overview of the cannabinergic system and mental health
title An integrative overview of the cannabinergic system and mental health
spellingShingle An integrative overview of the cannabinergic system and mental health
Oscar E. Prospéro García
Medicina
mental health
endocannabinoids
Cannabinoid system
cannabinoid receptor 1
cannabinoid receptor 2
title_short An integrative overview of the cannabinergic system and mental health
title_full An integrative overview of the cannabinergic system and mental health
title_fullStr An integrative overview of the cannabinergic system and mental health
title_full_unstemmed An integrative overview of the cannabinergic system and mental health
title_sort An integrative overview of the cannabinergic system and mental health
dc.creator.none.fl_str_mv Oscar E. Prospéro García
Pavel E. Rueda Orozco
Octavio Amancio Belmont
Alejandra E. Ruiz Contreras
Mónica Méndez Díaz
author Oscar E. Prospéro García
author_facet Oscar E. Prospéro García
Pavel E. Rueda Orozco
Octavio Amancio Belmont
Alejandra E. Ruiz Contreras
Mónica Méndez Díaz
author_role author
author2 Pavel E. Rueda Orozco
Octavio Amancio Belmont
Alejandra E. Ruiz Contreras
Mónica Méndez Díaz
author2_role author
author
author
author
dc.subject.none.fl_str_mv Medicina
mental health
endocannabinoids
Cannabinoid system
cannabinoid receptor 1
cannabinoid receptor 2
topic Medicina
mental health
endocannabinoids
Cannabinoid system
cannabinoid receptor 1
cannabinoid receptor 2
description Background. The endocannabinoid system (eCBs) is one of the modulatory systems widely expressed in the brain. It consists of receptors expressed in the cytoplasmic (CB1 and CB2), the mitochondrial membrane (CB1), and the endogenous ligands known as endocannabinoids, such as anandamide, 2AG and oleam - ide. CB1 has been found in excitatory and inhibitory neurons in the pre- and post-synaptic membranes. It is expressed in several brain areas such as the hippocampus, dorsal, and ventral striatum, amygdala and prefrontal cortex. The eCBs has been involved in the regulation of learning and memory, mood, energy bal- ance, sleep, and drug addiction. Objective. Integrate existing information about the eCBs and its role in brain function and mental health. Method. Review of the information of basic and clinical relevance obtained from indexed scientific journals (PubMed/Medline, Scopus). Results. Basic and clinical research on eCBs related to central nervous system function is described. Discussion and conclusion. At present, the study of eCBs is of importance. The development of drugs that affect this system may be clinically useful to control different debilitating diseases. This is an area of interest to the scientific community and health care providers.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0185-3325
https://www.redalyc.org/articulo.oa?id=58251633005
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identifier_str_mv 0185-3325
url https://www.redalyc.org/articulo.oa?id=58251633005
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dc.language.none.fl_str_mv en
language_invalid_str_mv en
dc.relation.none.fl_str_mv http://www.redalyc.org/revista.oa?id=582
dc.rights.none.fl_str_mv Salud Mental
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Salud Mental
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
publisher.none.fl_str_mv Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.source.none.fl_str_mv Salud Mental (México) Num.3 Vol.40
reponame:Redalyc-UNAM
instname:Universidad Nacional Autónoma de México
instacron:UNAM
instname_str Universidad Nacional Autónoma de México
instacron_str UNAM
institution UNAM
reponame_str Redalyc-UNAM
collection Redalyc-UNAM
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repository.mail.fl_str_mv
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