Synthesis of the steroidal glycoside (25R)-3 beta,16 beta-diacetoxy-12,22-dioxo-5 alpha-cholestan-26-yl beta-D-glucopyranoside and its anti-cancer properties on cervicouterine HeLa, CaSki, and ViBo cells

The synthesis of the new glycoside (25R)-3 beta,16 beta-diacetoxy-12,22-dioxo-5 alpha-cholestan-26-yl beta-D-glucopyranoside starting from hecogenin is described. This compound showed anti-cancer activity against cervicouterine cancer cells HeLa. CaSki and ViBo in the micromolar range. Its effect on...

Descripción completa

Detalles Bibliográficos
Autores: Fernandez-Herrera, MA, Mohan, S, Perez-Cervantes, E, Regla, I, Pinto, BM, Sandoval-Ramirez, J, Hernández-Vazquez, JMV, Escobar-Sánchez, ML, Sánchez-Sánchez, L, López-Muñoz, H
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:México
Institución:Universidad Nacional Autónoma de México
Repositorio:Sistema de Información de la Facultad de Ciencias, UNAM
OAI Identifier:oai:repositorio.fciencias.unam.mx:11154/34
Acceso en línea:http://hdlhandlenet/123456789/263
Access Level:acceso abierto
Palabra clave:Chemistry, Medicinal
Steroidal glycoside
HeLa
CaSki
ViBo
Antiproliferative activity
Apoptosis
Descripción
Sumario:The synthesis of the new glycoside (25R)-3 beta,16 beta-diacetoxy-12,22-dioxo-5 alpha-cholestan-26-yl beta-D-glucopyranoside starting from hecogenin is described. This compound showed anti-cancer activity against cervicouterine cancer cells HeLa. CaSki and ViBo in the micromolar range. Its effect on cell proliferation, cell cycle and cell death is also described. The cytotoxic effect of the title compound on HeLa, CaSki and ViBo cells and human lymphocytes was evaluated through the LDH released in the culture supernatant, indicating that the main cell death process is not necrosis

Similares en LA Referencia