Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis
The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predomin...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | México |
| Institución: | Universidad Autónoma de Zacatecas |
| Repositorio: | Repositorio Institucional Caxcán |
| Idioma: | inglés |
| OAI Identifier: | oai:http://ricaxcan.uaz.edu.mx:20.500.11845/705 |
| Acceso en línea: | http://localhost/xmlui/handle/20.500.11845/705 https://doi.org/10.48779/xdn7-p157 |
| Access Level: | acceso abierto |
| Palabra clave: | BIOLOGIA Y QUIMICA [2] Trichinella spiralis trichinellosis inflammatory response Th1 cytokine resiniferatoxin |
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Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in TrichinellosisMuñoz Carrillo, José LuísMuñoz López, José LuisMuñoz Escobedo, José JesúsMaldonado Tapia, ClaudiaGutiérrez Coronado, OscarContreras Cordero, Juan FranciscoMoreno García, María AlejandraBIOLOGIA Y QUIMICA [2]Trichinella spiralistrichinellosisinflammatory responseTh1 cytokineresiniferatoxinThe immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.The Korean Society for Parasitology and Tropical Medicinehttps://orcid.org/0000-0003-1324-44881202732019-02-28T18:20:00Z2019-02-28T18:20:00Z2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfinfo:eu-repo/semantics/publishedVersion0023-40011738-0006http://localhost/xmlui/handle/20.500.11845/705https://doi.org/10.48779/xdn7-p157Korean J Parasitol Vol. 55, No. 6, pp. 587-599reponame:Repositorio Institucional Caxcáninstname:Universidad Autónoma de Zacatecasinstacron:UAZenghttp://parasitol.kr/index.phpgeneralPublicGlobalAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de Américahttp://creativecommons.org/licenses/by-nc-sa/3.0/us/info:eu-repo/semantics/openAccessoai:http://ricaxcan.uaz.edu.mx:20.500.11845/7052024-08-28T03:21:18Z |
| dc.title.none.fl_str_mv |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| title |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| spellingShingle |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis Muñoz Carrillo, José Luís BIOLOGIA Y QUIMICA [2] Trichinella spiralis trichinellosis inflammatory response Th1 cytokine resiniferatoxin |
| title_short |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| title_full |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| title_fullStr |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| title_full_unstemmed |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| title_sort |
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis |
| dc.creator.none.fl_str_mv |
Muñoz Carrillo, José Luís Muñoz López, José Luis Muñoz Escobedo, José Jesús Maldonado Tapia, Claudia Gutiérrez Coronado, Oscar Contreras Cordero, Juan Francisco Moreno García, María Alejandra |
| author |
Muñoz Carrillo, José Luís |
| author_facet |
Muñoz Carrillo, José Luís Muñoz López, José Luis Muñoz Escobedo, José Jesús Maldonado Tapia, Claudia Gutiérrez Coronado, Oscar Contreras Cordero, Juan Francisco Moreno García, María Alejandra |
| author_role |
author |
| author2 |
Muñoz López, José Luis Muñoz Escobedo, José Jesús Maldonado Tapia, Claudia Gutiérrez Coronado, Oscar Contreras Cordero, Juan Francisco Moreno García, María Alejandra |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
https://orcid.org/0000-0003-1324-4488 120273 |
| dc.subject.none.fl_str_mv |
BIOLOGIA Y QUIMICA [2] Trichinella spiralis trichinellosis inflammatory response Th1 cytokine resiniferatoxin |
| topic |
BIOLOGIA Y QUIMICA [2] Trichinella spiralis trichinellosis inflammatory response Th1 cytokine resiniferatoxin |
| description |
The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-12 2019-02-28T18:20:00Z 2019-02-28T18:20:00Z |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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info:eu-repo/semantics/publishedVersion 0023-4001 1738-0006 http://localhost/xmlui/handle/20.500.11845/705 https://doi.org/10.48779/xdn7-p157 |
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info:eu-repo/semantics/publishedVersion 0023-4001 1738-0006 |
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http://localhost/xmlui/handle/20.500.11845/705 https://doi.org/10.48779/xdn7-p157 |
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eng |
| language |
eng |
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http://parasitol.kr/index.php generalPublic |
| dc.rights.none.fl_str_mv |
Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-sa/3.0/us/ info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-sa/3.0/us/ |
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openAccess |
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application/pdf |
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Global |
| dc.publisher.none.fl_str_mv |
The Korean Society for Parasitology and Tropical Medicine |
| publisher.none.fl_str_mv |
The Korean Society for Parasitology and Tropical Medicine |
| dc.source.none.fl_str_mv |
Korean J Parasitol Vol. 55, No. 6, pp. 587-599 reponame:Repositorio Institucional Caxcán instname:Universidad Autónoma de Zacatecas instacron:UAZ |
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Universidad Autónoma de Zacatecas |
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UAZ |
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UAZ |
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Repositorio Institucional Caxcán |
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Repositorio Institucional Caxcán |
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