Autoantibodies against Cajal bodies in systemic lupus erythematosus

Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those in...

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Autores: Vázquez Talavera, José, Ramírez Sandoval, Roxana, Esparza Ibarra, Edgar León, Ávalos Díaz, Esperanza del Refugio, Herrera Esparza, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:México
Institución:Universidad Autónoma de Zacatecas
Repositorio:Repositorio Institucional Caxcán
Idioma:español
OAI Identifier:oai:http://ricaxcan.uaz.edu.mx:20.500.11845/623
Acceso en línea:http://hdl.handle.net/20.500.11845/623
Access Level:acceso abierto
Palabra clave:BIOLOGIA Y QUIMICA [2]
systemic lupus erythematous p80 coilin
small nuclear ribonucleoprotein particles (snRNPs)
pre-mRNA processing
autoantibodies
immunofluorescence
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spelling Autoantibodies against Cajal bodies in systemic lupus erythematosusVázquez Talavera, JoséRamírez Sandoval, RoxanaEsparza Ibarra, Edgar LeónÁvalos Díaz, Esperanza del RefugioHerrera Esparza, RafaelBIOLOGIA Y QUIMICA [2]systemic lupus erythematous p80 coilinsmall nuclear ribonucleoprotein particles (snRNPs)pre-mRNA processingautoantibodiesimmunofluorescenceCajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those involved in pre-mRNA processing. The aim of the present investigation is to assess the presence of anti-CB autoantibodies in a cohort of SLE sera. Material/Methods: Antinuclear antibodies (ANA) were screened by indirect immunofluorescence in a batch of 190 sera from patients who met the ACR criteria for SLE classification; fine specificity was determined by Western blot using HEp-2 cells or rat hepatocyte extracts purified by ion exchange chromatography. Results: Four sera had anti-Cajal body (CB) autoantibodies. Interestingly, all of these patients had intermittent extensive oral and esophageal ulceration. The autoantibodies to CB were of the IgG class, and by Western blot these sera had reactivity against an 80 kDa protein (coilin) associated with Sm proteins. Conclusions: Anti-CB autoantibodies constitute an uncommon specificity of SLE; therefore it seems that anti-CB antibody specificity is associated with extensive mucous ulceration.International Scientific Information76919449544942018-08-08T19:24:51Z2018-08-08T19:24:51Z2004-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfinfo:eu-repo/semantics/publishedVersion1643-3750http://hdl.handle.net/20.500.11845/623Med Sci Monit, Vol. 10, Núm. 5, 2004.reponame:Repositorio Institucional Caxcáninstname:Universidad Autónoma de Zacatecasinstacron:UAZspahttp://www.MedSciMonit.com/pub/vol_10/no_5/4137.pdfgeneralPublicGlobalAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de Américahttp://creativecommons.org/licenses/by-nc-sa/3.0/us/info:eu-repo/semantics/openAccessoai:http://ricaxcan.uaz.edu.mx:20.500.11845/6232024-08-28T03:20:23Z
dc.title.none.fl_str_mv Autoantibodies against Cajal bodies in systemic lupus erythematosus
title Autoantibodies against Cajal bodies in systemic lupus erythematosus
spellingShingle Autoantibodies against Cajal bodies in systemic lupus erythematosus
Vázquez Talavera, José
BIOLOGIA Y QUIMICA [2]
systemic lupus erythematous p80 coilin
small nuclear ribonucleoprotein particles (snRNPs)
pre-mRNA processing
autoantibodies
immunofluorescence
title_short Autoantibodies against Cajal bodies in systemic lupus erythematosus
title_full Autoantibodies against Cajal bodies in systemic lupus erythematosus
title_fullStr Autoantibodies against Cajal bodies in systemic lupus erythematosus
title_full_unstemmed Autoantibodies against Cajal bodies in systemic lupus erythematosus
title_sort Autoantibodies against Cajal bodies in systemic lupus erythematosus
dc.creator.none.fl_str_mv Vázquez Talavera, José
Ramírez Sandoval, Roxana
Esparza Ibarra, Edgar León
Ávalos Díaz, Esperanza del Refugio
Herrera Esparza, Rafael
author Vázquez Talavera, José
author_facet Vázquez Talavera, José
Ramírez Sandoval, Roxana
Esparza Ibarra, Edgar León
Ávalos Díaz, Esperanza del Refugio
Herrera Esparza, Rafael
author_role author
author2 Ramírez Sandoval, Roxana
Esparza Ibarra, Edgar León
Ávalos Díaz, Esperanza del Refugio
Herrera Esparza, Rafael
author2_role author
author
author
author
dc.contributor.none.fl_str_mv 76919
4495
4494
dc.subject.none.fl_str_mv BIOLOGIA Y QUIMICA [2]
systemic lupus erythematous p80 coilin
small nuclear ribonucleoprotein particles (snRNPs)
pre-mRNA processing
autoantibodies
immunofluorescence
topic BIOLOGIA Y QUIMICA [2]
systemic lupus erythematous p80 coilin
small nuclear ribonucleoprotein particles (snRNPs)
pre-mRNA processing
autoantibodies
immunofluorescence
description Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those involved in pre-mRNA processing. The aim of the present investigation is to assess the presence of anti-CB autoantibodies in a cohort of SLE sera. Material/Methods: Antinuclear antibodies (ANA) were screened by indirect immunofluorescence in a batch of 190 sera from patients who met the ACR criteria for SLE classification; fine specificity was determined by Western blot using HEp-2 cells or rat hepatocyte extracts purified by ion exchange chromatography. Results: Four sera had anti-Cajal body (CB) autoantibodies. Interestingly, all of these patients had intermittent extensive oral and esophageal ulceration. The autoantibodies to CB were of the IgG class, and by Western blot these sera had reactivity against an 80 kDa protein (coilin) associated with Sm proteins. Conclusions: Anti-CB autoantibodies constitute an uncommon specificity of SLE; therefore it seems that anti-CB antibody specificity is associated with extensive mucous ulceration.
publishDate 2004
dc.date.none.fl_str_mv 2004-05-01
2018-08-08T19:24:51Z
2018-08-08T19:24:51Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv info:eu-repo/semantics/publishedVersion
1643-3750
http://hdl.handle.net/20.500.11845/623
identifier_str_mv info:eu-repo/semantics/publishedVersion
1643-3750
url http://hdl.handle.net/20.500.11845/623
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://www.MedSciMonit.com/pub/vol_10/no_5/4137.pdf
generalPublic
dc.rights.none.fl_str_mv Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Global
dc.publisher.none.fl_str_mv International Scientific Information
publisher.none.fl_str_mv International Scientific Information
dc.source.none.fl_str_mv Med Sci Monit, Vol. 10, Núm. 5, 2004.
reponame:Repositorio Institucional Caxcán
instname:Universidad Autónoma de Zacatecas
instacron:UAZ
instname_str Universidad Autónoma de Zacatecas
instacron_str UAZ
institution UAZ
reponame_str Repositorio Institucional Caxcán
collection Repositorio Institucional Caxcán
repository.name.fl_str_mv
repository.mail.fl_str_mv
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