Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia
Ultrathin oral films are novel delivery systems that do not require water to swallow, show rapid systemic release, and allow a comfortable and precise dosage. These films represent an option for administering active metabolites from medicinal plants used against insomnia, such as Agastache mexicana....
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | México |
| Institución: | UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO |
| Repositorio: | TIP Revista especializada en ciencias químico-biológicas |
| Idioma: | español |
| OAI Identifier: | oai:ojs.ojs.escire.net:article/465 |
| Acceso en línea: | http://tip.zaragoza.unam.mx/index.php/tip/article/view/465 |
| Access Level: | acceso abierto |
| Palabra clave: | ultrathin films; Agastache mexicana; oral administration; insomnia películas ultradelgadas; Agastache mexicana; administración oral; insomnio |
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Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomniaPelículas orales ultradelgadas con extractos de Agastache mexicana con actividad hipnótica como potencial tratamiento del insomnioMartínez-Cortés, Dulce MaribelVera-Pérez, JonathanGómez-y-Gómez, Yolandaultrathin films; Agastache mexicana; oral administration; insomniapelículas ultradelgadas; Agastache mexicana; administración oral; insomnioUltrathin oral films are novel delivery systems that do not require water to swallow, show rapid systemic release, and allow a comfortable and precise dosage. These films represent an option for administering active metabolites from medicinal plants used against insomnia, such as Agastache mexicana. However, incorporating complex bioactive molecules can compromise the functionality of the films. This study evaluated the physicochemical properties and biological activity of sodium alginate films added with the ethanolic extracts of Agastache Mexicana. After incorporating the extracts, the films preserved their homogeneous morphology, thickness (<50 µm), and solubility time (<10 min). In contrast, hardness increased more than 40%, and elasticity increased 60%. Infrared spectroscopy analysis revealed that, after the preparation of the films, the functional groups of the extracts and the chemical structure of the ultrathin films were maintained. Moreover, we demonstrated that the hypnotic effect of Agastache mexicana was preserved, since the sleep onset latency and total sleep time in a murine model were similar between the liquid extract and the film formulation. These data support the use of ultrathin films with natural extracts as a potential treatment for sleep disorders like insomnia.Las películas orales ultradelgadas son sistemas de administración novedosos que no requieren agua para ingerirlas, son de rápida liberación sistémica y permiten una dosificación cómoda y precisa, representan una opción para el suministro de metabolitos de plantas medicinales usadas para problemas de insomnio como Agastache mexicana. Sin embargo, la incorporación de moléculas complejas puede alterar la función de las películas. Por ello, el objetivo de esta investigación fue el análisis de la reacción fisicoquímica de las películas ultradelgadas de alginato de sodio y su actividad biológica al mezclarlas con los extractos etanólicos de A. mexicana. Se observó que después de integrar los extractos, las películas conservaron su morfología homogénea, grosor menor a 50 µm, y un tiempo de solubilidad por debajo de los 10 min., mientras que la dureza y la elasticidad se incrementaron más del 40% y 60% respectivamente. Mediante el uso de la espectroscopía infrarroja encontramos que los grupos funcionales de los extractos se conservan y no modifican la estructura química de las películas ultradelgadas. Adicionalmente, demostramos que las películas conservan el efecto hipnótico de Agastache mexicana, ya que los tiempos de latencia y de sueño en un modelo murino no sufrieron cambios significativos, lo que significa un potencial tratamiento de origen natural ante desórdenes del sueño como el insomnio.Universidad Nacional Autónoma de México2022-08-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttp://tip.zaragoza.unam.mx/index.php/tip/article/view/46510.22201/fesz.23958723e.2022.465TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 25 (2022)2395-87231405-888X10.22201/fesz.23958723e.2022reponame:TIP Revista especializada en ciencias químico-biológicasinstname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOinstacron:UNAMspahttp://tip.zaragoza.unam.mx/index.php/tip/article/view/465/399http://tip.zaragoza.unam.mx/index.php/tip/article/view/465/503Copyright (c) 2022 TIP Revista Especializada en Ciencias Químico-Biológicasinfo:eu-repo/semantics/openAccessoai:ojs.ojs.escire.net:article/4652024-08-16T20:18:08Z |
| dc.title.none.fl_str_mv |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia Películas orales ultradelgadas con extractos de Agastache mexicana con actividad hipnótica como potencial tratamiento del insomnio |
| title |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| spellingShingle |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia Martínez-Cortés, Dulce Maribel ultrathin films; Agastache mexicana; oral administration; insomnia películas ultradelgadas; Agastache mexicana; administración oral; insomnio |
| title_short |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| title_full |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| title_fullStr |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| title_full_unstemmed |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| title_sort |
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia |
| dc.creator.none.fl_str_mv |
Martínez-Cortés, Dulce Maribel Vera-Pérez, Jonathan Gómez-y-Gómez, Yolanda |
| author |
Martínez-Cortés, Dulce Maribel |
| author_facet |
Martínez-Cortés, Dulce Maribel Vera-Pérez, Jonathan Gómez-y-Gómez, Yolanda |
| author_role |
author |
| author2 |
Vera-Pérez, Jonathan Gómez-y-Gómez, Yolanda |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
ultrathin films; Agastache mexicana; oral administration; insomnia películas ultradelgadas; Agastache mexicana; administración oral; insomnio |
| topic |
ultrathin films; Agastache mexicana; oral administration; insomnia películas ultradelgadas; Agastache mexicana; administración oral; insomnio |
| description |
Ultrathin oral films are novel delivery systems that do not require water to swallow, show rapid systemic release, and allow a comfortable and precise dosage. These films represent an option for administering active metabolites from medicinal plants used against insomnia, such as Agastache mexicana. However, incorporating complex bioactive molecules can compromise the functionality of the films. This study evaluated the physicochemical properties and biological activity of sodium alginate films added with the ethanolic extracts of Agastache Mexicana. After incorporating the extracts, the films preserved their homogeneous morphology, thickness (<50 µm), and solubility time (<10 min). In contrast, hardness increased more than 40%, and elasticity increased 60%. Infrared spectroscopy analysis revealed that, after the preparation of the films, the functional groups of the extracts and the chemical structure of the ultrathin films were maintained. Moreover, we demonstrated that the hypnotic effect of Agastache mexicana was preserved, since the sleep onset latency and total sleep time in a murine model were similar between the liquid extract and the film formulation. These data support the use of ultrathin films with natural extracts as a potential treatment for sleep disorders like insomnia. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-08-08 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://tip.zaragoza.unam.mx/index.php/tip/article/view/465 10.22201/fesz.23958723e.2022.465 |
| url |
http://tip.zaragoza.unam.mx/index.php/tip/article/view/465 |
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10.22201/fesz.23958723e.2022.465 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
http://tip.zaragoza.unam.mx/index.php/tip/article/view/465/399 http://tip.zaragoza.unam.mx/index.php/tip/article/view/465/503 |
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Copyright (c) 2022 TIP Revista Especializada en Ciencias Químico-Biológicas info:eu-repo/semantics/openAccess |
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Copyright (c) 2022 TIP Revista Especializada en Ciencias Químico-Biológicas |
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openAccess |
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application/pdf application/xml |
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Universidad Nacional Autónoma de México |
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Universidad Nacional Autónoma de México |
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TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 25 (2022) 2395-8723 1405-888X 10.22201/fesz.23958723e.2022 reponame:TIP Revista especializada en ciencias químico-biológicas instname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO instacron:UNAM |
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TIP Revista especializada en ciencias químico-biológicas |
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TIP Revista especializada en ciencias químico-biológicas |
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