Nanobodies: Biotechnological development and applications

Monoclonal antibodies are one the most revolutionary tools in the biomedicine area for having immunotherapeutic and immunodiagnostic applications. However, the rapid technological advance demanded by these areas generates the exploration of new biomolecules. The discovery of antibodies composed sole...

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Autores: Ortega-Portilla, Paola Andrea, Cancino-Villeda, Laura, Coronado-Aceves, Enrique Wenceslao, Espitia-Pinzón, Clara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:México
Institución:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Repositorio:TIP Revista especializada en ciencias químico-biológicas
Idioma:español
OAI Identifier:oai:ojs.ojs.escire.net:article/398
Acceso en línea:http://tip.zaragoza.unam.mx/index.php/tip/article/view/398
Access Level:acceso abierto
Palabra clave:antibody; Nanobodies; cancer; immunotherapy; pharmaceutical industry
nanoanticuerpos; Nanobodies; cáncer; inmunoterapia; industria farmacéutica
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spelling Nanobodies: Biotechnological development and applicationsNanoanticuerpos: desarrollo biotecnológico y aplicacionesOrtega-Portilla, Paola AndreaCancino-Villeda, LauraCoronado-Aceves, Enrique WenceslaoEspitia-Pinzón, Claraantibody; Nanobodies; cancer; immunotherapy; pharmaceutical industrynanoanticuerpos; Nanobodies; cáncer; inmunoterapia; industria farmacéuticaMonoclonal antibodies are one the most revolutionary tools in the biomedicine area for having immunotherapeutic and immunodiagnostic applications. However, the rapid technological advance demanded by these areas generates the exploration of new biomolecules. The discovery of antibodies composed solely of heavy chains, naturally present in the camelids’ serum and some shark species, has been the subject of study since the last decades as an alternative to conventional antibodies. These have an antigen recognition region, which consists of a variable domain for each chain, known as single domain antibodies or nanobodies. These biomolecules are characterized by having a small size, high specificity, stability, and low cost in their production; properties that make them a highly versatile tool. This review will address relevant aspects of nanobodies, such as their discovery, structural characteristics, development in the field of biotechnology, and their potential for application in diseases such as cancer and in the identification of microorganisms.Los anticuerpos monoclonales son una de las herramientas más revolucionarias en el área de la biomedicina por tener aplicaciones inmunoterapéuticas e inmunodiagnósticas. Sin embargo, el rápido avance tecnológico que demandan estas áreas genera la exploración de nuevas biomoléculas. El descubrimiento de anticuerpos compuestos únicamente por cadenas pesadas, presentes de forma natural en el suero de los camélidos y en algunas especies de tiburón, son motivo de estudio desde las últimas décadas como una alternativa a los anticuerpos convencionales. Estos poseen una región de reconocimiento antigénico, que consiste en un dominio variable por cada cadena, conocidos como anticuerpos de un solo dominio o nanoanticuerpos. Estas biomoléculas se caracterizan por tener un tamaño reducido, alta especificidad, estabilidad y bajo costo en su producción; propiedades que las convierten en una herramienta altamente versátil. En la presente revisión se abordarán aspectos relevantes de los nanoanticuerpos, como su descubrimiento, características estructurales, desarrollo en el campo de la biotecnología y su potencial de aplicación en enfermedades como el cáncer y en la identificación de microorganismos.Universidad Nacional Autónoma de México2021-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttp://tip.zaragoza.unam.mx/index.php/tip/article/view/39810.22201/fesz.23958723e.2021.398TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 24 (2021)2395-87231405-888X10.22201/fesz.23958723e.2021.0reponame:TIP Revista especializada en ciencias químico-biológicasinstname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOinstacron:UNAMspahttp://tip.zaragoza.unam.mx/index.php/tip/article/view/398/384http://tip.zaragoza.unam.mx/index.php/tip/article/view/398/476Copyright (c) 2021 TIP Revista Especializada en Ciencias Químico-Biológicasinfo:eu-repo/semantics/openAccessoai:ojs.ojs.escire.net:article/3982024-08-16T20:18:09Z
dc.title.none.fl_str_mv Nanobodies: Biotechnological development and applications
Nanoanticuerpos: desarrollo biotecnológico y aplicaciones
title Nanobodies: Biotechnological development and applications
spellingShingle Nanobodies: Biotechnological development and applications
Ortega-Portilla, Paola Andrea
antibody; Nanobodies; cancer; immunotherapy; pharmaceutical industry
nanoanticuerpos; Nanobodies; cáncer; inmunoterapia; industria farmacéutica
title_short Nanobodies: Biotechnological development and applications
title_full Nanobodies: Biotechnological development and applications
title_fullStr Nanobodies: Biotechnological development and applications
title_full_unstemmed Nanobodies: Biotechnological development and applications
title_sort Nanobodies: Biotechnological development and applications
dc.creator.none.fl_str_mv Ortega-Portilla, Paola Andrea
Cancino-Villeda, Laura
Coronado-Aceves, Enrique Wenceslao
Espitia-Pinzón, Clara
author Ortega-Portilla, Paola Andrea
author_facet Ortega-Portilla, Paola Andrea
Cancino-Villeda, Laura
Coronado-Aceves, Enrique Wenceslao
Espitia-Pinzón, Clara
author_role author
author2 Cancino-Villeda, Laura
Coronado-Aceves, Enrique Wenceslao
Espitia-Pinzón, Clara
author2_role author
author
author
dc.contributor.none.fl_str_mv

dc.subject.none.fl_str_mv antibody; Nanobodies; cancer; immunotherapy; pharmaceutical industry
nanoanticuerpos; Nanobodies; cáncer; inmunoterapia; industria farmacéutica
topic antibody; Nanobodies; cancer; immunotherapy; pharmaceutical industry
nanoanticuerpos; Nanobodies; cáncer; inmunoterapia; industria farmacéutica
description Monoclonal antibodies are one the most revolutionary tools in the biomedicine area for having immunotherapeutic and immunodiagnostic applications. However, the rapid technological advance demanded by these areas generates the exploration of new biomolecules. The discovery of antibodies composed solely of heavy chains, naturally present in the camelids’ serum and some shark species, has been the subject of study since the last decades as an alternative to conventional antibodies. These have an antigen recognition region, which consists of a variable domain for each chain, known as single domain antibodies or nanobodies. These biomolecules are characterized by having a small size, high specificity, stability, and low cost in their production; properties that make them a highly versatile tool. This review will address relevant aspects of nanobodies, such as their discovery, structural characteristics, development in the field of biotechnology, and their potential for application in diseases such as cancer and in the identification of microorganisms.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://tip.zaragoza.unam.mx/index.php/tip/article/view/398
10.22201/fesz.23958723e.2021.398
url http://tip.zaragoza.unam.mx/index.php/tip/article/view/398
identifier_str_mv 10.22201/fesz.23958723e.2021.398
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://tip.zaragoza.unam.mx/index.php/tip/article/view/398/384
http://tip.zaragoza.unam.mx/index.php/tip/article/view/398/476
dc.rights.none.fl_str_mv Copyright (c) 2021 TIP Revista Especializada en Ciencias Químico-Biológicas
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 TIP Revista Especializada en Ciencias Químico-Biológicas
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Universidad Nacional Autónoma de México
publisher.none.fl_str_mv Universidad Nacional Autónoma de México
dc.source.none.fl_str_mv TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 24 (2021)
2395-8723
1405-888X
10.22201/fesz.23958723e.2021.0
reponame:TIP Revista especializada en ciencias químico-biológicas
instname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
instacron:UNAM
instname_str UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
instacron_str UNAM
institution UNAM
reponame_str TIP Revista especializada en ciencias químico-biológicas
collection TIP Revista especializada en ciencias químico-biológicas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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