Association of the estrogen receptor alpha gene polymorphisms with osteoporosis in the Mexican population

The estrogen receptor gene (ER alpha) has been implicated in the development of osteoporosis. In this study, the association of two ER alpha gene polymorphic markers (a TA dinucleotide repeat and a single nucleotide polymorphism, G2014A) with osteoporosis was tested in 70 osteoporotic women, 70 non-...

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Bibliographic Details
Authors: Gomez, R, Magana, JJ, Cisneros, B, Perez-Salazar, E, Faugeron, S, Veliz, D, Castro, C, Rubio, J, Casas, L, Valdes-Flores, M
Format: article
Status:Published version
Publication Date:2007
Country:México
Institution:Universidad Nacional Autónoma de México
Repository:Sistema de Información de la Facultad de Ciencias, UNAM
OAI Identifier:oai:repositorio.fciencias.unam.mx:11154/2254
Online Access:http://hdl.handle.net/11154/2254
Access Level:Open access
Keyword:Genetics & Heredity
bone mineral density
dinucleotide polymorphism
estrogen receptor alpha gene
osteoporosis
single nucleotide polymorphism
Description
Summary:The estrogen receptor gene (ER alpha) has been implicated in the development of osteoporosis. In this study, the association of two ER alpha gene polymorphic markers (a TA dinucleotide repeat and a single nucleotide polymorphism, G2014A) with osteoporosis was tested in 70 osteoporotic women, 70 non-osteoporotic women and 500 subjects from the Mexican population. According to the genetic analysis of the Mexican population using eight unlinked polymorphic markers, we found that our population is structured into three subpopulations

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