Paroxysmal starting and stopping of circulating waves in excitable media

Levels of intracellular Ca2+ were monitored using fluorescence from Ca2+-sensitive dyes in chick embryonic heart cells cultured in an annular geometry. There was spontaneous starting and stopping of reentrant waves of activity. The results are modeled using modified FitzHugh-Nagumo equations represe...

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Bibliographic Details
Authors: Nagai, Y, Shrier, A, Glass, L, González, H
Format: article
Status:Published version
Publication Date:2000
Country:México
Institution:Universidad Nacional Autónoma de México
Repository:Sistema de Información de la Facultad de Ciencias, UNAM
OAI Identifier:oai:repositorio.fciencias.unam.mx:11154/3282
Online Access:http://hdl.handle.net/11154/3282
Access Level:Open access
Keyword:Physics, Multidisciplinary
Description
Summary:Levels of intracellular Ca2+ were monitored using fluorescence from Ca2+-sensitive dyes in chick embryonic heart cells cultured in an annular geometry. There was spontaneous starting and stopping of reentrant waves of activity. The results are modeled using modified FitzHugh-Nagumo equations representing pacemakers embedded in a conducting medium. These results provide a potential mechanism for spontaneous abnormal cardiac rhythms in which there are rapid heart beats (tachycardias) that repetitively start and stop.

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