Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis
This study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the −670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria. Additionally, a...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | México |
| Institución: | Universidad Autónoma de Zacatecas |
| Repositorio: | Repositorio Institucional Caxcán |
| Idioma: | español |
| OAI Identifier: | oai:http://ricaxcan.uaz.edu.mx:20.500.11845/2174 |
| Acceso en línea: | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174 https://doi.org/10.48779/nwst-k854 |
| Access Level: | acceso abierto |
| Palabra clave: | MEDICINA Y CIENCIAS DE LA SALUD [3] lupus nephritis (LN) soluble Fas (sFas) systemic lupus erythematosus (SLE) |
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Soluble Fas and the −670 Polymorphism of Fas in Lupus NephritisBollain y Goytia, Juan JoséArellano Rodríguez, MarielaTorres del Muro, Felipe de JesúsDaza Benitez, LeonelMuñoz Valle, José FranciscoAvalos Díaz, Esperanza del RefugioHerrera Esparza, RafaelMEDICINA Y CIENCIAS DE LA SALUD [3]lupus nephritis (LN)soluble Fas (sFas)systemic lupus erythematosus (SLE)This study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the −670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria. Additionally, a group of 54 healthy subjects (HS) was included. The allelic frequency of the−670 polymorphism of Fas was determined using PCR-RFLP analysis, and sFas levels were assessed by ELISA. Additionally, the WT-1 protein level in urine was measured. The Fas receptor was determined in biopsies by immunohistochemistry (IHC) and in situ hybridization (FISH) and apoptotic features by TUNEL. Results. The −670 Fas polymorphism showed that the G allele was associated with increased SLE susceptibility, with an odds ratio (OR) of 1.86. The sFas was significantly higher in LN patients with the G/G genotype, and this subgroup exhibited correlations between the sFas level and proteinuria and increased urinary WT1 levels. LN group shows increased expression of Fas and apoptotic features. In conclusion, our results indicate that the G allele of the −670 polymorphism of Fas is associated with genetic susceptibility in SLE patients with elevated levels of sFas in LN with proteinuria.Hindawihttps://orcid.org/0000-0002-3403-984984378449544942020-12-03T16:42:33Z2020-12-03T16:42:33Z2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfinfo:eu-repo/semantics/publishedVersion2090-214X2090-2158http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174https://doi.org/10.48779/nwst-k854International Journal of Nephrology Volume 2014, Article ID 780406, 10 páginasreponame:Repositorio Institucional Caxcáninstname:Universidad Autónoma de Zacatecasinstacron:UAZspahttps://www.hindawi.com/journals/ijn/2014/780406/https://doi.org/10.1155/2014/780406generalPublicGlobalAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de Américahttp://creativecommons.org/licenses/by-nc-sa/3.0/us/info:eu-repo/semantics/openAccessoai:http://ricaxcan.uaz.edu.mx:20.500.11845/21742024-08-28T03:21:47Z |
| dc.title.none.fl_str_mv |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| title |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| spellingShingle |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis Bollain y Goytia, Juan José MEDICINA Y CIENCIAS DE LA SALUD [3] lupus nephritis (LN) soluble Fas (sFas) systemic lupus erythematosus (SLE) |
| title_short |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| title_full |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| title_fullStr |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| title_full_unstemmed |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| title_sort |
Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis |
| dc.creator.none.fl_str_mv |
Bollain y Goytia, Juan José Arellano Rodríguez, Mariela Torres del Muro, Felipe de Jesús Daza Benitez, Leonel Muñoz Valle, José Francisco Avalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael |
| author |
Bollain y Goytia, Juan José |
| author_facet |
Bollain y Goytia, Juan José Arellano Rodríguez, Mariela Torres del Muro, Felipe de Jesús Daza Benitez, Leonel Muñoz Valle, José Francisco Avalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael |
| author_role |
author |
| author2 |
Arellano Rodríguez, Mariela Torres del Muro, Felipe de Jesús Daza Benitez, Leonel Muñoz Valle, José Francisco Avalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
https://orcid.org/0000-0002-3403-9849 84378 4495 4494 |
| dc.subject.none.fl_str_mv |
MEDICINA Y CIENCIAS DE LA SALUD [3] lupus nephritis (LN) soluble Fas (sFas) systemic lupus erythematosus (SLE) |
| topic |
MEDICINA Y CIENCIAS DE LA SALUD [3] lupus nephritis (LN) soluble Fas (sFas) systemic lupus erythematosus (SLE) |
| description |
This study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the −670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria. Additionally, a group of 54 healthy subjects (HS) was included. The allelic frequency of the−670 polymorphism of Fas was determined using PCR-RFLP analysis, and sFas levels were assessed by ELISA. Additionally, the WT-1 protein level in urine was measured. The Fas receptor was determined in biopsies by immunohistochemistry (IHC) and in situ hybridization (FISH) and apoptotic features by TUNEL. Results. The −670 Fas polymorphism showed that the G allele was associated with increased SLE susceptibility, with an odds ratio (OR) of 1.86. The sFas was significantly higher in LN patients with the G/G genotype, and this subgroup exhibited correlations between the sFas level and proteinuria and increased urinary WT1 levels. LN group shows increased expression of Fas and apoptotic features. In conclusion, our results indicate that the G allele of the −670 polymorphism of Fas is associated with genetic susceptibility in SLE patients with elevated levels of sFas in LN with proteinuria. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-11 2020-12-03T16:42:33Z 2020-12-03T16:42:33Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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info:eu-repo/semantics/publishedVersion 2090-214X 2090-2158 http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174 https://doi.org/10.48779/nwst-k854 |
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info:eu-repo/semantics/publishedVersion 2090-214X 2090-2158 |
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http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174 https://doi.org/10.48779/nwst-k854 |
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spa |
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spa |
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https://www.hindawi.com/journals/ijn/2014/780406/ https://doi.org/10.1155/2014/780406 generalPublic |
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Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-sa/3.0/us/ info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-sa/3.0/us/ |
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application/pdf |
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Hindawi |
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Hindawi |
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International Journal of Nephrology Volume 2014, Article ID 780406, 10 páginas reponame:Repositorio Institucional Caxcán instname:Universidad Autónoma de Zacatecas instacron:UAZ |
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Universidad Autónoma de Zacatecas |
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