Regulación del metabolismo por el GDF11 en células derivadas de tumores hepáticos
Cancer cells are characterized by alterations in key metabolic pathways to fulfill the biosynthetic demands associated with proliferation. Part of this phenotype is translated in a significant reliance in the use of glucose as an energy source, and a greater synthesis of lipids to favor cell prolife...
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| Formato: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | México |
| Recursos: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:zw12z542h |
| Acesso em linha: | https://doi.org/10.24275/uami.zw12z542h |
| Access Level: | acceso abierto |
| Palavra-chave: | info:eu-repo/classification/LEM/Biology, Experimental info:eu-repo/classification/LEM/Lípidos -- Metabolismo info:eu-repo/classification/LEM/Lipids -- Metabolism info:eu-repo/classification/LEM/Biología experimental info:eu-repo/classification/LEM/Liver -- Cancer info:eu-repo/classification/LEM/Hígado -- Cáncer info:eu-repo/classification/cti/2 |
| Resumo: | Cancer cells are characterized by alterations in key metabolic pathways to fulfill the biosynthetic demands associated with proliferation. Part of this phenotype is translated in a significant reliance in the use of glucose as an energy source, and a greater synthesis of lipids to favor cell proliferation. The growth differentiation factor 11 (GDF11/ BMP11), a member of TGF-β superfamily, has recently been described as an important regulator of proliferation and differentiation in cells that maintain stem characteristics. However, the role it plays in cells that demand a greater amount of energy, as in the case of hepatocellular carcinoma (HCC), has not yet been characterized. Our results indicate that GDF11 induces an anti-tumorigenic effect in hepatocellular carcinoma cell lines associated with the outcome that exert on glycolysis and lipid metabolism. These results show that GDF11 could be an important factor in the control of hepatocellular carcinoma. |
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