Encapsulación de ficocianina en una matriz polimérica de quitosano-TPP por gelación ionotrópica
Phycocyanin is a protein present in Spirulina, it has different biological activities such as antioxidant, anti-inflammatory, antitumor and immunomodulatory capacity that make it a biocompound with potential to treat diseases, however, it presents stability and availability problems when administere...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | México |
| Institución: | UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO |
| Repositorio: | PÄDI Boletín Científico de Ciencias Básicas e Ingeniería del ICBI |
| Idioma: | español |
| OAI Identifier: | oai:repository.uaeh.edu.mx:article/11826 |
| Acceso en línea: | https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/view/11826 |
| Access Level: | acceso abierto |
| Palabra clave: | ionotropic gelation chitosan nanoparticles phycocyanin gelación ionotrópica quitosano nanopartículas ficocianina |
| Sumario: | Phycocyanin is a protein present in Spirulina, it has different biological activities such as antioxidant, anti-inflammatory, antitumor and immunomodulatory capacity that make it a biocompound with potential to treat diseases, however, it presents stability and availability problems when administered in biological systems. In this project, it was proposed to encapsulate phycocyanin in a chitosan polymer matrix to protect it from pH, temperature and physiological conditions that compromise its biological activity. The ionotropic gelation technique and tripolyphosphate (TPP) were used as a cross-linking agent. Different ratios of chitosan and TPP, as well as protein, were tested. The best results were obtained with the 9:1 ratio and 10% protein concentration, obtaining 12.6 and 33.21% charge and association efficiency respectively. Through FTIR spectroscopy, the interaction between the amino groups of chitosan and phosphate could be verified. of the TPP, the particle solution presented a surface charge of -37.3 mV and a polydispersity percentage of 84.4. |
|---|