On the evolution of the single-subunit RNA polymerases
Many eukaryotic nuclear genomes as well as mitochondrial plasmids contain genes displaying evident sequence similarity to those encoding the single-subunit RNA polymerase (ssRNAP) of bacteriophage T7 and its relatives. We have collected and aligned these ssRNAP sequences and have constructed unroote...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 1997 |
| País: | México |
| Recursos: | Universidad Nacional Autónoma de México |
| Repositório: | Sistema de Información de la Facultad de Ciencias, UNAM |
| OAI Identifier: | oai:repositorio.fciencias.unam.mx:11154/3355 |
| Acesso em linha: | http://hdl.handle.net/11154/3355 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Biochemistry & Molecular Biology Evolutionary Biology Genetics & Heredity RNA polymerase evolution mitochondria bacteriophage linear plasmid phylogenetic tree |
| Resumo: | Many eukaryotic nuclear genomes as well as mitochondrial plasmids contain genes displaying evident sequence similarity to those encoding the single-subunit RNA polymerase (ssRNAP) of bacteriophage T7 and its relatives. We have collected and aligned these ssRNAP sequences and have constructed unrooted phylogenetic trees that demonstrate the separation of ssRNAPs into three well-defined and nonoverlapping clusters (phage-encoded, nucleus-encoded, and plasmid-encoded). Our analyses indicate that these three subfamiles of T7-1ike RNAPs shared a common ancestor |
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