Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank

Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank database for RNAs that contain hammerhead or h...

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Autores: Ferbeyre, G, Bourdeau, V, Pageau, M, Miramontes, P, Cedergren, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:México
Institución:Universidad Nacional Autónoma de México
Repositorio:Sistema de Información de la Facultad de Ciencias, UNAM
OAI Identifier:oai:repositorio.fciencias.unam.mx:11154/2590
Acceso en línea:http://hdl.handle.net/11154/2590
Access Level:acceso abierto
Palabra clave:Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
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spelling Distribution of hammerhead and hammerhead-like RNA motifs through the GenBankFerbeyre, GBourdeau, VPageau, MMiramontes, PCedergren, RBiochemistry & Molecular BiologyBiotechnology & Applied MicrobiologyGenetics & HeredityHammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank database for RNAs that contain hammerhead or hammerhead-like motifs. The search shows a widespread distribution of this kind of RNA motif in different sequences suggesting that they might have a more general role in RNA biology. The frequency of the hammerhead motif is half of that expected from a random distribution, but this fact comes From the low CpG representation in vertebrate sequences and the bias of the GenBank for those sequences. Intriguing motifs include those found in several families of repetitive sequences, in the satellite RNA from the carrot red leaf luteovirus, in plant viruses like the spinach latent virus and the elm mottle virus, in animal viruses like the hepatitis E virus and the caprine encephalitis virus, and in mRNAs such as those coding for cytochrome P450 oxidoreductase in the rat and the hamster.2011-01-22T10:28:07Z2011-01-22T10:28:07Z2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1088-9051http://hdl.handle.net/11154/2590249210(7):1011-1019reponame:Sistema de Información de la Facultad de Ciencias, UNAMinstname:Universidad Nacional Autónoma de Méxicoinstacron:UNAMenGenome Researchinfo:eu-repo/semantics/openAccessoai:repositorio.fciencias.unam.mx:11154/25902025-09-17T19:21:09Z
dc.title.none.fl_str_mv Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
title Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
spellingShingle Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
Ferbeyre, G
Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
title_short Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
title_full Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
title_fullStr Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
title_full_unstemmed Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
title_sort Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank
dc.creator.none.fl_str_mv Ferbeyre, G
Bourdeau, V
Pageau, M
Miramontes, P
Cedergren, R
author Ferbeyre, G
author_facet Ferbeyre, G
Bourdeau, V
Pageau, M
Miramontes, P
Cedergren, R
author_role author
author2 Bourdeau, V
Pageau, M
Miramontes, P
Cedergren, R
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
topic Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
description Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank database for RNAs that contain hammerhead or hammerhead-like motifs. The search shows a widespread distribution of this kind of RNA motif in different sequences suggesting that they might have a more general role in RNA biology. The frequency of the hammerhead motif is half of that expected from a random distribution, but this fact comes From the low CpG representation in vertebrate sequences and the bias of the GenBank for those sequences. Intriguing motifs include those found in several families of repetitive sequences, in the satellite RNA from the carrot red leaf luteovirus, in plant viruses like the spinach latent virus and the elm mottle virus, in animal viruses like the hepatitis E virus and the caprine encephalitis virus, and in mRNAs such as those coding for cytochrome P450 oxidoreductase in the rat and the hamster.
publishDate 2000
dc.date.none.fl_str_mv 2000
2011-01-22T10:28:07Z
2011-01-22T10:28:07Z
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1088-9051
http://hdl.handle.net/11154/2590
2492
identifier_str_mv 1088-9051
2492
url http://hdl.handle.net/11154/2590
dc.language.none.fl_str_mv en
language_invalid_str_mv en
dc.relation.none.fl_str_mv Genome Research
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv 10(7):1011-1019
reponame:Sistema de Información de la Facultad de Ciencias, UNAM
instname:Universidad Nacional Autónoma de México
instacron:UNAM
instname_str Universidad Nacional Autónoma de México
instacron_str UNAM
institution UNAM
reponame_str Sistema de Información de la Facultad de Ciencias, UNAM
collection Sistema de Información de la Facultad de Ciencias, UNAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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