Genomic Instability Decreases in HIV Patient by Complementary Therapy with Rosmarinus officinalis Extracts

Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extracts of Rosmarinus officinalis on genomic instability in HIV patients. We studied 67 HIV pa...

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Detalhes bibliográficos
Autores: Lazalde Ramos, Blanca Patricia, Zamora Perez, Ana Lourdes, Ortega Guerrero, Aymée Ileana, Quintero Fraire, Saira Zulema, Palacios Lara, Omar, Quirarte Báez, Sol María, Galaviz Hernández, Carlos, Sosa Macías, Martha, Ortiz García, Yveth Marlene, Morales Velazquez, Gabriela
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Recursos:Universidad Autónoma de Zacatecas
Repositorio:Repositorio Institucional Caxcán
Idioma:español
OAI Identifier:oai:http://ricaxcan.uaz.edu.mx:20.500.11845/2597
Acesso em linha:http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2597
https://doi.org/10.48779/qdx6-z724
Access Level:acceso abierto
Palavra-chave:BIOLOGIA Y QUIMICA [2]
oxidative stress
human immunodeficiency virus (HIV)
Rosmarinus officinalis
Descrição
Resumo:Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extracts of Rosmarinus officinalis on genomic instability in HIV patients. We studied 67 HIV patients under pharmacological treatment with ATRIPLA who were divided into three groups: group 1, patients under ATRIPLA antiretroviral therapy; group 2, patients with ATRIPLA and rosemary aqueous extract (4 g/L per day); and group 3, patients with ATRIPLA and rosemary methanolic extract (400 mg/day). The genomic instability was evaluated through the buccal micronucleus cytome assay. Oral epithelial cells were taken at the beginning and 1 and 4 months later. The groups that received the pharmacological therapy with ATRIPLA and the complementary therapy with R. officinalis extracts showed a decrease in the number of cells with micronuclei and nuclear abnormalities compared with the group that only received ATRIPLA. The complementary therapy with R. officinalis decreased the genomic instability in HIV patients.

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