Fibrillarin from Archaea to human
Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and r...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | México |
| Institución: | Centro de Investigación Científica de Yucatán |
| Repositorio: | Repositorio Institucional CICY |
| Idioma: | inglés |
| OAI Identifier: | oai:cicy.repositorioinstitucional.mx:1003/1075 |
| Acceso en línea: | http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1075 |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/Autores/CANCER info:eu-repo/classification/Autores/METHYLATION info:eu-repo/classification/Autores/P53 info:eu-repo/classification/Autores/RIBOSOMAL BIOGÉNESIS info:eu-repo/classification/Autores/RNA PROCESSING info:eu-repo/classification/cti/2 |
| Sumario: | Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection. |
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