Cytotoxic activity of casearborin c isolated from casearia corymbosa
Casearborin c (1), syringic acid (2), ent-3β-hydroxy-(-)-13-epi-manoyl oxide (3), ent-(-)-13-epi-manoyl oxide (4), ent-(-)-kaur-16-en-19-oic acid (5), and γ-sitosterol (6) were isolated from Casearia corymbosa stem bark. Only casearborin c showed cytotoxic activity on HeLa and SiHa cancer cell lines...
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | México |
| Recursos: | Centro de Investigación Científica de Yucatán |
| Repositorio: | Repositorio Institucional CICY |
| Idioma: | inglés |
| OAI Identifier: | oai:cicy.repositorioinstitucional.mx:1003/1529 |
| Acesso em linha: | http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1529 |
| Access Level: | acceso abierto |
| Palavra-chave: | info:eu-repo/classification/Autores/SALICACEAE info:eu-repo/classification/Autores/CASEARIA CORYMBOSA info:eu-repo/classification/Autores/CYTOTOXIC ACTIVITY info:eu-repo/classification/Autores/DITERPENES info:eu-repo/classification/Autores/CLERODANES info:eu-repo/classification/Autores/CASEARBORIN C info:eu-repo/classification/cti/2 |
| Resumo: | Casearborin c (1), syringic acid (2), ent-3β-hydroxy-(-)-13-epi-manoyl oxide (3), ent-(-)-13-epi-manoyl oxide (4), ent-(-)-kaur-16-en-19-oic acid (5), and γ-sitosterol (6) were isolated from Casearia corymbosa stem bark. Only casearborin c showed cytotoxic activity on HeLa and SiHa cancer cell lines. This work contributes to the description of three compounds (1-3) newly isolated from C. corymbosa and highlights that casearborin c, a clerodane-type diterpene, is responsible for the cytotoxic activity shown in the original methanol extract of this species. |
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