Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconcl...

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Autores: Solans, Marta, Castelló, Adela, Benavente, Yolanda, Marcos-Gragera, Rafael, Amiano, Pilar, Gracia-Lavedan, Esther, Costas, Laura, Robles, Claudia, Gonzalez-Barca, Eva, Banda, Esmeralda de la, Alonso, Esther, Aymerich, Marta, Campo, Elias, Dierssen Sotos, Trinidad|||0000-0002-6127-0077, Fernández-Tardón, Guillermo, Olmedo-Requena, Rocio, Gimeno, Eva, Castaño-Vinyals, Gemma, Aragonés, Nuria, Kogevinas, Manolis
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/15813
Acceso en línea:http://hdl.handle.net/10902/15813
Access Level:acceso abierto
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spelling Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain studySolans, MartaCastelló, AdelaBenavente, YolandaMarcos-Gragera, RafaelAmiano, PilarGracia-Lavedan, EstherCostas, LauraRobles, ClaudiaGonzalez-Barca, EvaBanda, Esmeralda de laAlonso, EstherAymerich, MartaCampo, EliasDierssen Sotos, Trinidad|||0000-0002-6127-0077Fernández-Tardón, GuillermoOlmedo-Requena, RocioGimeno, EvaCastaño-Vinyals, GemmaAragonés, NuriaKogevinas, ManolisDiet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.Predoctoral contract to MS (CIBERESP), Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900. Spanish Ministry of Economy and Competitiveness - Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF) - a way to build Europe [(grants PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, Rio Hortega CM13/00232, SV-09-CLINIC-1 and Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP))] and the Agència de Gestió d'Ajuts Universitaris i de Recerca AGAUR (2017SGR1085, 2014SGR756). The ICGC CLL-Genome Project was funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII), PMP15/00007 and Centro de Investigación Biomédica en Red: Oncología (CIBERONC). ISGlobal is a member of the CERCA Programme, Generalitat de CatalunyaFerrata Storti FoundationUniversidad de Cantabria20182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/15813Haematologica. 2018 Nov;103(11):1881-1888reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/158132026-06-02T12:39:31Z
dc.title.none.fl_str_mv Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
spellingShingle Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
Solans, Marta
title_short Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_full Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_fullStr Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_full_unstemmed Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_sort Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
dc.creator.none.fl_str_mv Solans, Marta
Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
Banda, Esmeralda de la
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen Sotos, Trinidad|||0000-0002-6127-0077
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
author Solans, Marta
author_facet Solans, Marta
Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
Banda, Esmeralda de la
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen Sotos, Trinidad|||0000-0002-6127-0077
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
author_role author
author2 Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
Banda, Esmeralda de la
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen Sotos, Trinidad|||0000-0002-6127-0077
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/15813
url http://hdl.handle.net/10902/15813
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ferrata Storti Foundation
publisher.none.fl_str_mv Ferrata Storti Foundation
dc.source.none.fl_str_mv Haematologica. 2018 Nov;103(11):1881-1888
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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